BIOLOGICAL PRODUCTS (VETERINARY). 
681 
the washed red corpuscles of a sheep (hemolytic amboceptor), 
normal serum of a guinea pig (complement) and washed red 
corpuscles of a sheep. The test is based on the phenomena of 
hemolysis and bacteriolysis and is of such a complicated nature 
that it must necessarily be a laboratory test. In substance the 
test may be briefly described as follows,—the specific immune 
bodies, (bacteriolytic amboceptor) in the serum of glandered 
animals combined with the antigen (glanders bacilli extract) and 
the complement. When the hemolytic amboceptor and its an¬ 
tigen (red corpuscles) are added later, no hemolysis will take 
place because one of the factors (complement) necessary to ac¬ 
complish this is not available, as it has combined with the gland¬ 
ers antigen and bacteriolytic amboceptor. On the other hand if 
the serum under test is from an animal free from glanders, it 
will not contain the bacteriolytic amboceptor, and the comple¬ 
ment will be free to unite with the hemolytic amboceptor and 
antigen, with the result that hemolysis will occur as evidenced 
by the liberation of hemoglobin in the fluid. 
This test is recognized by some authorities as being the most 
reliable method for the diagnosis of glanders. It is used to some 
extent in the detection of contagious abortion in cattle. 
The above list includes the principal and most practical bio¬ 
logical products used in veterinary medicine at the present time. 
Since their advent they have aided materially in the diagnosis, 
prevention and treatment of many of the specific infectious dis¬ 
eases of animals and have enabled the veterinarian to accom¬ 
plish better results in his fight against disease than was possible 
with some of the former methods of treatment, which were more 
or . less empirical in nature. 
If medical research is as fruitful in the future as it has been 
in the past, it would seem that the time is not far distant when 
practically every form of infection can be successfully combated 
with a biological specific. 
New York State Fair and Horse Show, at Syracuse, Sep¬ 
tember 9 to 14. 
