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r. Kocpi. 
ing and knot-forming showed itself upon the up-to-that-time completely healed 
inoculation-wound. After this the enlargement of the lymph-glands increased 
rapidly, often to the size of ahazel nut. The knot at the point of inoculation then 
mostly broke out and covered itself with a dry crust, under which was aflat abscess 
not discharging much pus and provided with a caseous base. The animals then 
began to grow emaciated, to have rough hair and difficulty in breathing and died 
usually from the fourth to the eight week, or were killed within this period. Also 
in the case of rabbits the inoculating substance was a few times put into a pocket¬ 
shaped skin-wound. But since the course of the disease did not run so precisely 
and so quickly after the subcutaneous inoculation as was the case with guinea pigs, 
I afterwards chose the anterior eye chamber as the point of inoculation in rabbits. 
The course of the iris-tuberculosis arising in consequence of this inoculation has 
been described often and therefore does not need a special description. The fol¬ 
lowing inoculations were carried out in this manner: 
1. Miliary tuberculosis.— Tuberculous knots of the pia mater, very rich in 
tuberculous bacilli: six guinea pigs. Of these one died in five weeks, two in six 
weeks, two in seven weeks after the inoculation. The sixth was killed in the 
eighth week. In all the animals the lungs, liver and spleen were tuberculous in a 
high degree and the inguinal glands were caseous. 
2. Miliary tuberculosis. —Grey little knots of the lung, quite rich in tuber¬ 
culous bacilli: six guinea pigs. Three died in the sixth week, the others were 
killed a few days later. All tuberculous as in No. 1. 
3. Miliary tuberculosis. --Grey yellow knots from the spleen and kidney, 
not very rich in tuberculous bacilli: six guinea pigs. Died in the sixth and seventh 
week. All tuberculous as in No. 1. 
4. Miliary tuberculosis. —Grey knots of the lung, quite rich in bacilli: three 
guinea pigs. Two died in the sixth, one in the seventh week. All tuberculous 
as in No. 1. 
5. Miliary tuberculosis. —Grey knots of the lung containing few bacilli; 
five guinea pigs, two rabbits at the “ root of the ear.” One guinea pig died after 
eight weeks, the others were killed a few days later. All tuberculous. The rabbits 
killed after ten weeks had caseous lymph-glands at the root of the ear and on the 
neck, quite a uumber of grey little knots in the lungs and some knots in the 
kidneys and in the spleen. Five guinea pigs were inocalated with tubercles from 
the spleen of one of the guinea pigs. Of these three died in the eighth week, the 
other two were killed in the same week and all found tuberculous. Further, the 
caseous gland substance of the rabbits rubbed in water, was injected into the belly 
cavity of two rabbits. When these animals were killed eight weeks later, tuber¬ 
culosis of the omentum, spleen and liver existed as also quite a number of grey 
knots in both lungs. 
6. Gaseous pneumonia and tuberculosis of the brain-membranes. —Two 
guinea pigs witti the bacilli-rich lung-substance, one guinea pig with a piece of 
the tuberculously infiltrated and bacilli-rich pia mater. The animals died in the 
fifth and sixth week. Both tuberculous. 
7. Caseously infiltrated lung. —Six guinea pigs. The first died after six 
weeks. The others were already very sick and were killed on the following day. 
All tuberculous. 
