' • ’ t 
226 EXPERIMENTAL PATHOLOGY. 
its use for such a secondary purpose, and of course it becomes 
necessary to select some other organism, if not equally avail¬ 
able, as nearly so as possible. The rabbit, which has been 
made the subject of trial, is comparatively valueless for the 
purpose, the product of inoculation being little more than an 
insignificant ulcer slow in its development, and not always fol¬ 
lowed by generalized symptoms. The field mouse has been 
shown by Messrs. Lceffler and Schutz to be possessed of an 
excessive sensitiveness to the action of the bacillus of glan¬ 
ders, dying in a space of time varying between two and eight 
days, exhibiting moreover extensive and characteristic visceral 
lesions. But it is not always easy to obtain these animals, and 
as moreover they show a greater susceptibility to septicaemia 
than to glanders, and as the septic and glanderous elements 
may become combined, both as to the virus which is injected 
and the resulting lesions, the result can scarcely be trusted as 
furnishing any reliable testimony, such as the careful practi¬ 
tioner should always demand, and the field mouse must also 
be rejected as of no practical utility in the case in hand. 
The availability of the guinea pig is next brought to the 
test. Messrs. Christol and Kiener were the first to experi¬ 
ment with these animals, and to prove their susceptibility to 
glanders. When inoculated under the skin, they generally 
die in from twenty-five to fifty days, during which period they 
not only exhibit the glanderous abscess at the point of inocu¬ 
lation, but also lesions of the lymphatic glands ; of the liver ; 
the spleen ; the articulations and surrounding tissues; and 
also, the lesions of the testicles, to which I will now call spe¬ 
cial attention. 
It is ordinarily ten or twelve days after a sub-cutaneous 
inoculation that the testicles become tumefied, the swelling 
being at first about the size of a walnut, or even larger ; the 
scrotal skin becoming tense, red and shining, and often break¬ 
ing and allowing the escape of glanderous pus. This constant 
elective localization in the testicles in guinea pigs is altogether 
characteristic of glanders. 
When instead of inoculating under the skin, I have intro¬ 
duced the virus into the peritoneal cavity, I have observed 
