CAN GLANDERS BE PREVENTED BV INOCULATION ? 
271 
which is supported by all known evidence, that it is not to be 
done by the method of artificially mitigated cultures of their 
specific germs, as is the case in exogenous diseases such as 
rouget-rothlauf of swine, hen cholera, black leg, anthrax and 
the swine plague, the southern cattle plague (Texas fever) and 
typhus and yellow fever in man and such strictly septicmmic 
diseases, but rather by following the precedent of variola and 
its prevention by vaccina, or in other words, by the continual 
transmission of the disease for generations through the organ¬ 
ism of some moderately susceptible animal, in which it does 
not prove fatal, until it arrives at a given constancy of miti¬ 
gated virulence which, while still capable of producing a pro¬ 
tecting disease in the species of animals in which such a dis¬ 
ease occurs, under natural conditions, does not produce it in 
such a form as to render such inoculated animals dangerous 
to others of the same species. This is exactly what occurs in 
vaccination. In this regard I have long thought that such 
results might possibly be acquired by the successive produc¬ 
tion of cutaneous glanders in dogs. 
This hypothesis has been engaging my thought for a long 
time, and I was not only pleased, but somewhat surprised, to 
see that introductory steps in this direction had been entered 
upon by one of my French confreres, whose communication 
is just published in the “ Comptes Rendus," Tome c. VIII, No. 
io, 1889, p. 530, of which is offered a very free translation. 
Mr. Strauss says : “ Glanders is considered to be a viru¬ 
lent malady for which there exists no immunity. The exper¬ 
iments which I have made do not agree with such a conclu¬ 
sion. We know that the dog possesses but a feeble degree of 
receptivity to glanders infection, for when by scarification or 
incision, we insert glanders material under, or into, the cutis 
of this animal, a local ulceration follows characterized by 
spontaneous cicatrization at the end of a month or six weeks; 
it is not common to see the disseminated or constitutional 
lesions of the disease, with death, follow such a procedure in 
the dog.” 
In my experiments I have adopted another course, viz : I 
have directly introduced pure cultures of the germ of glan- 
