484 
WM. S. GOTTHEIL. 
means, are full of wise suggestion, and the remarks which he 
offers relating to the use of digestive preparations, or of 
stomachic compounds, and principally of pepsins, should not 
be ignored by those who may be called to treat youngsters 
affected by diarrhoea. The preparations of pepsine which are 
offered for sale by the house of Parke, Davis & Co., of De¬ 
troit, seem to possess all the qualities required by the indica¬ 
tions, and from statements we have already received of the 
good results obtained by the use of the concentrated glycerole , 
and of the elixir , we believe that we have done well in bring¬ 
ing the subject before our readers. The reports which we 
have now at hand are few, but are very satisfactory, and we 
would be pleased to hear further from those who may have 
opportunities to try them. Though these preparations have 
not yet entered very largely into veterinary practice, having 
been principally confined to the domain of human medicine, 
the comparative pathologist cannot ignore them, and is in 
duty bound to the profession to try for himself whether their 
use is not followed by adequate benefit in his own sphere of 
observation and knowledge. 
ORIGINAL ARTICLES. 
HOW DO MICRO-ORGANISMS CAUSE DISEASE? 
Based upon an address by Ludwig Brieger to the Sixty-second Verscunmburg 
Deutscher Nat urf or seller u Aertzte. 
By Wm. S. Gottheil, M.D., Professor of Surgical Pathology to the 
American Veterinary College. 
The latter half of the nineteenth century will be known in 
medical annals as the era of etiological discovery. We have, 
indeed, of late years grown so accustomed to results which in 
former times would have been considered the medical won¬ 
der of the age, that they pass by us almost without our 
knowledge, and certainly without our appreciation of their 
importance. If we reflect that but a few years ago the ra¬ 
tionale and exact cause of an immense class of diseases, in- 
