-668 
J. LAW. 
though they took the whole of the milk furnished by their re¬ 
spective nurses, and they have thriven better when weaned and 
put upon solid food alone. I have followed some such calves 
until they grew up and were slaughtered, and have made post¬ 
mortem examintions and found them bearing old calcified tuber¬ 
cles pointing back to the time when they sucked the infected and 
poisonous milk. It is idle to say that such milk was merely lack¬ 
ing in nutritive principles. The calves in question had access to 
other food, while following their nurses, and would have taken 
no harm from swallowing an equal amount of pure water. Apart 
from the bacilli, which operates slowly, and which allowed these 
animals to live for years and even to thrive after they had 
ceased taking the milk, there was unquestionably in this secre¬ 
tion a definite poison which undermined the health and stimu¬ 
lated the progress of the tuberculous process. Accessions of 
bacilli in the milk are not denied, but at the worst these acted 
tardily, and apart from the soluble poisons, their action must 
been cumulative up to the cessation of the milk diet, so that 
immediately after its withdrawal the morbid action should have 
been greater than at any time before, and it should have ad¬ 
vanced with a rapidity proportionate to the impetus thus ac¬ 
quired. But in these cases improvement dated from the change 
to the dry coarse food, implying rather the withdrawal of a 
poison which had been heretofore acting continuously but 
which had no power of self-multiplication after the fashion of 
the bacillus. 
K. Yamagiva, in his experiments on guinea-pigs, obtained 
results confirmatory of this. After inoculation with tubercle, 
the administration of “tuberculin” greatly hastened the onset of 
generalized tuberculosis, so that after a week tuberculous foci 
were found in lymphatic glands, liver and lungs. 
In this connection it is worthy of notice that man is much 
more susceptible to “tuberculin” than many of the lower ani¬ 
mals. A healthy guinea-pig, weighing a pound, is little or not 
at all affected by a dose of 2 cc. (Nocard), while a healthy man, 
weighing 150 lbs., is seriously affected by a dose of 0.05 cc., 
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