226 
E. LEOLAINCHE AND L. MONTANE. 
formed by an old hemorrhage, is spread around the nodule, 
and at this point the vesicles contain granular or fibrillar 
hbrine, discolored, red corpuscles, and large, round cells. 
“ These are simply endothelial cells of the lung, which, be¬ 
coming active and globular, are thus enabled to surround and 
envelop, and destroy the red corpuscles.” 
The very complex alterations of chronic glanders have been 
the object of numerous researches. *Dupuy has recognized 
in the pulmonary tubercle the anatomical characteristics of 
the disease, and insists upon the absolute diagnostic significa¬ 
tion of the lesion, and he considers glanders in the horse as 
analogous to “ tuberculous disease ” in man. 
fVirchow, who undertakes the histologic analysis of the 
neoformation, confirms the resemblance established between 
glanderous granulation and the true tubercle. Both are due 
to a proliferation of the nuclei of the conjunctive tissue, due 
to an acrid or irritating agent, and constituted by an agglom¬ 
eration of small cells, and by the elastic fibres of the primitive 
tissue. Thus formed, the nodules undergo, in their central 
part, a caseous degeneration. And again, melastatic altera¬ 
tions may be seen in the lung, under the form of irregular 
centers, projecting above the inflamed parenchyma, and 
possessing most commonly the characters of the parts affected 
with lobular pneumonia. They sometimes assume large 
dimensions, as those of a nut or an apple, and soften and form 
a mass of detritus, and then much resembe the great cen¬ 
ters of tuberculous infiltration. 
ifRavitsch systematically defines the glanderous lesion to 
be a thrombosis of the venous and lymphatic vessels, giving 
rise to disturbances of nutrition in the surrounding parts. 
In its incipiency, the tubercle is indicated only by a fibrinous 
intra-alveolar exudate, containing some leucocytes, but later 
*Dupuy, de l’affection tuberculeuse vulgairemtnt appelie movde—Paris 1817. 
•f Handbuch der specielle Patho. 1855, vol. II., p. 405—Patliol. dcs tumeurs 
—1869, vol. II., p. 541. 
JRavitsch, Einige Worte ueber die Pathogenese der Rotz und Wurmkrank- 
heit des Pferdes, Virchow’s Arch., 1892, vol. XXIII., p. 33. 
