STUDY OF PULMONARY GLANDERS. 
227 
inflammation appears and gives origin to the alveolar mem¬ 
brane, with a multiplication of the fixed elements of the tissue. 
*Leisering confirms the ideas of Virchow in regard to the 
histological constitution of the tubercle. He admits that the 
lesion is developed in the interstitial connective tissue, under 
the influence of a contagium received directly into the paren¬ 
chyma by the inspired air. 
He also mentions a peculiar anatomical form (infiltrated 
glanders) characterized by diffuse inflammations of the con¬ 
nective tissue, and at times spreading between the lobules, 
around the bronchia and blood vessels. 
fTrasbot and Cornil give a concise description of a 
glanderous granulation, developed around a bronchia. This 
tissue is constituted by numerous fibres of elastic laminous 
tissue, forming an extremely close network, in which are 
found spherical nuclei, some of which are surrounded with 
protoplasmic granulations. 
$ 
^Rabe publishes a very good study of the pathological 
anatomy of the various localizations of glanders.. The pul¬ 
monary tubercle develops itself in the centre of the paren¬ 
chyma, and includes a varying number of alveoli. At the 
beginning, a thickening of the partitions occurs ; then these, in¬ 
filtrated with nuclei, give the idea of a tissue in a condition 
of rapid proliferation; round cells are also found in the alve¬ 
oli, and a more complete examination shows that these cells 
are specially abundant around the capillaries, and that, in 
reality, the tissue of granulation starts from the surface of 
the capillaries, which are the source of the round or elliptic 
elements which infiltrate the tissue ; the alveoli and the 
alveolar epithelium have no part in their production. At a 
later period, the alveolar cavities are entirely filled with a tis¬ 
sue of granulation, which may form into cellular tissue, while 
*Leis* ring, zur Pathologischen Anatomie des R'tzes,Sachs Veterin. Bericht, 
1862. 
fTrasb )t and Cornil. Note sur la structure des granulations morvenses du 
cheval: Soc. de Biolog. 1866, vol. XVII., p. 218. 
JRibe, zur Pathologischen Anatomie und Histologie der Rotz Krankheit, 
Talvarber K. Thierarzmischule zu Hannover, 1877-1881. 
