VIRULENCE OF BLOOD AND MUSCLES IN TUBERCULOSIS. 229 
formed of epithelioid cells, among which at times giant cells 
appear; then comes a fibrinous zone, .which surrounds the 
others and tightly presses them ; and then a zone of intersti¬ 
tial pneumonia, frequently containing epithelioid and giant 
cells in its alveoli. 
This concise review is sufficient to show that the lesions of 
glanders with slow growth are as yet incompletely determined 
as to their form, though much discussed as to their signifi¬ 
cance. In the researches which we have prosecuted it has been 
principally our design to determine certain points of study 
which would probably be the most advantageous and inter¬ 
esting to pursue. 
(To be continued). 
VIRULENCE OF THE BLOOD AND MUSCLES IN TUBERCULOSIS. 
*By J. M’Fadyean, M.B., B.So., F.R.S.E., Royal Vet. College, Edinburgh. 
Ought tuberculosis to be regarded as a disease totius 
substantice —one in which the agents of infection are distrib¬ 
uted throughout the entire system, or is it in the majority 
of cases a local affection ? 
Considering the immense amount of research that has 
within the past two decades been devoted to tuberculosis, it 
is not a little surprising that opinion should still be sharply 
divided regarding this point, which is one of supreme im¬ 
portance from its bearing on the etiology and prophylaxis of 
the disease. 
If tuberculosis is in the vast majority of cases a local 
disease, in which the bacilli are confined to the visibly altered 
parts at or near the point where they have found a port 
of entrance into the tissues, it is obviously improbable that 
hereditary transmission can play a great role in the propaga¬ 
tion of the disease. Again, if tubercle bacilli are only 
exceptionally distributed throughout the entire body, the 
ground is to a large extent cut from the feet of those who 
maintain that the total seizure of every tuberculous carcase 
♦Reprint from Journal of Comparative Pathology and Therapeutics. 
