232 
.T. m’fADYEAN. 
that in one animal the liver contained a few white specks of 
psorospermosis. 
Experiment II.—This experiment was almost an exact 
repetition of the foregoing one, save that only 2 rabbits were 
inoculated, and that the quantity of blood injected into each 
was 5 cc. The cow from which the blood'was taken was the 
subject of extensive tuberculosis of the lungs and bronchial 
glands. 
Both rabbits were killed 40 days after inoculation. In one 
of them the post-mortem revealed no lesion whatever; the 
liver of the other contained a few white specks of psoro¬ 
spermosis, but the peritoneum and all the other organs were 
healthy. 
In neither of these two experiments was the distribution 
of the lesions in the cow from which the blood was taken 
such as to indicate a generalized tuberculosis. In the follow¬ 
ing three experiments the blood was taken from horses in 
which the conditions of a generalized tuberculosis had been 
experimentally produced by injecting tubercle bacilli into the 
blood stream. Each horse was infected as follows: about a 
tablespoonful of caseo-pus from a tuberculous tumor of the 
spleen of a horse was well shaken in a test tube with 30 cc. of 
sterilized tap-water. The milky fluid thus obtained was 
poured into a conical glass and allowed to stand for a few 
minutes until the coarser particles had settled to the bottom. 
Eight cc. of the still milky upper strata of the liquid were 
then sucked into a syringe and injected into the jugular vein 
of each of the three horses. What I have here termed caseo- 
pus is the diffluent whitish material which in some cases of 
equine tuberculosis constitutes the bulk of the tumors found 
in the spleen, and which, in my experience, is above every 
other form of tuberculous lesion rich in bacilli. The annexed 
figure is from a photograph 1 of a cover-glass preparation 
made from the liquid injected into the jugular vein of the 
horse referred to in Experiment IV. When it is reflected 
1 This photograph was kindly made for me by Mr. P. D. Coghill of the 
Royal Veterinary College, London. 
