VIRULENCE OF BLOOD AND MUSCLES IN TUBERCULOSIS. 235 
Experiment II.—The material used for inoculation in 
this case was the juice expressed from the muscular tissue of 
a horse into whose jugular vein an enormous number of 
tubercle bacilli had been injected sixteen days prior to its 
death. Of this juice 5 cc. were injected into the peritoneum 
of each of two guinea-pigs. 
Both guinea-pigs were killed 21 days after inoculation, 
and the post-mortem showed the peritoneum and all the organs 
of the body Iree from tuberculosis. 
Experiment III.—This experiment was an exact repeti¬ 
tion of the preceding one, save that 22 days had elapsed 
between the intra venous inoculation and the death of the 
horse from whose muscles the juice was obtained. 
The two guinea-pigs were killed 26 days after inoculation, 
and both were found to be free from any trace of tuberculous 
lesions. 
The view that the*blood-stream is the carrier of tubercle 
bacilli in most if not all cases of tuberculosis has within 
recent years repeatedly been expressed, and it may be said 
that this view is tacitly subscribed to by all those who demand 
total seizure as the only safe method of dealing with the flesh 
of tuberculous cattle, for if the muscular tissue in general is 
the seat of the tuberculous virus it can only be in consequence 
of the arrest of tubercle bacilli circulating in the blood cur¬ 
rent. There does not appear to me to be anything like 
sufficient evidence to prove the correctness of this opinion. 
Indeed, I would go further, and say that the available evi¬ 
dence furnished by experiment, or drawn from a considera¬ 
tion of the common distribution of the lesions in natural cases 
of bovine tuberculosis, abundantly warrants the conclusion 
that in the vast majority of cases tubercle bacilli are not 
carried by the blood-stream, and that there is no general 
infection of the muscular or glandular system. 
I intend on another occasion to revert to the evidence 
regarding this point that is derivable from the distribution of 
the lesions in cases of natural and experimental tuberculosis 
in the larger animals, but in the present article I wish to re¬ 
view the experimental evidence relied upon by the’advocates 
