304 
E. LECLAINCHE AND L. MONTANE. 
marks of alveoli which have disappeared; and an external 
zone, fibro-embryonal, due to an accumulation of young- 
rounded cells, widely nucleated, and mixed with delicate 
connective fasciculi. Bacilli have completely disappeared, 
or, at least, can no longer be made apparent to the unaided 
vision. At the periphery of the nodule, the pulmonary struc¬ 
ture is permeable; yet the walls of the vesicles are thickened 
by an embryonic neoformation, and hold together only by 
means of the external fibrous layer. 
Thus constituted, the tubercle undergoes none but regres¬ 
sive alterations with external manifestations. The epitheloid 
zone gradually disappears, as the result of the degeneration 
of the internal limitating surface and of the growth of the 
external fibrous envelope. At a later period, there remains 
but the amorphous granular contents, enclosed in a resisting 
capsule, composed of concentric connective fasciculi inti¬ 
mately united, and containing between them a lew connec¬ 
tive cells. 
B.— Alterations of the Lymphatic Tracts. 
These alterations, which precede and accompany the evolu¬ 
tion of the glanders tubercle, are constituted essentially by a 
gathering of leucocytes in all regions overrun by the bacilli. 
The sub-pleural connective tissue, and that of the interlob¬ 
ular bands, are from their origin oedematous and infiltrated. 
The conjunctive cells are plainly visible, and their anastomo¬ 
tic branches form a well-marked cellular network, whose 
alveola are filled with migrating cells, both isolated and gath¬ 
ered into small groups. Some have a large nucleolus and a 
thin layer of protoplasm; others a small nucleoles and a 
definite protoplasmic zone. 
Again, in some places, the leucocytes are accumulated in 
more compact and extended patches, regularly rounded, and 
situated in the center of the dislocated connective tissue. 
The cellular elements, strongly colored, are enclosed by a fine 
reticulum. 
Again these foci of leucocytes may be agglomerated, and 
constitute by their reunion a peculiarly interesting form, re- 
