STUDY OF PULMONARY GLANDERS* 
375 
ginning of alteration ; their nuclei are in process of segmen¬ 
tation. Among those which contain one or several bacilli, 
some seem yet intact, while others show a broken, granular 
nucleoli, with their outlines scarcely indicated. 
In some places the inflammatory troubles are very marked, 
and reach to the total destruction of the walls and the ob¬ 
struction of the vessel. Then, under a section, a wide zone of 
embryonic tissue appears containing several muscular, smooth 
cells, the remains of the middle tunic, and occupying the 
lumen of the vessel, a granulation of embryonic tissue. 
Lesions of similar order are met near the bronchi. The 
leucocytal infiltration of the peri-bronchic lymphatic tissue is 
followed by the inflammatory reaction of the walls. The 
dermis of the mucous membrane, infiltrated with numerous 
migrating cells, thickens and granulates in the interior of the 
canal, while at the same time the epithelium proliferates and 
falls off. The leucocytes break through the walls and form 
on some projecting point granulations which practically close 
it. With them bacilli enter the bronchi, and they are seen 
sometimes in very large numbers, encased in the immigrated 
cellular elements and the loosened epithelium, into a'mucous 
exudate which fills up the bronchial cul-de-sacs. 
The granulating of the walls going on, the cavity is 
gradually obstructed and subsequently completely obliterated 
in some places by an inflammatory granulation. 
III. 
The preceding observations, though incomplete, present 
an outline of the principal methods of pulmonary infection. 
The bacilli are first met in the lymphatic tracts, and slowly 
progressing they give rise at every point to stasis of the 
lymph and to an abundant leucocytosis. These very mani¬ 
fest lesions were not overlooked by the first observers. They 
are those which constitute the “ infiltrated glanders ” of Leis- 
ering and the “lymphatic oedema” of Rabe. But their 
pathogeny is very different from that which they gave it, 
since, instead of constituting a passive phenomenon, the sim¬ 
ple mechanical result of an obstacle to the circulation more 
