376 
E. LECLAINCHE AND L. MONTANE. 
or less distant, they are an expression of an active process of 
reaction, due to the presence of the bacilli, and instead of ex¬ 
pressing a secondary and accessory accident, the lymphatic 
oedema explains the primordial and essential fact of the in¬ 
fection. 
The lymphatic glands enact the part of vector of the virus, 
and this fact is interesting, in that it shows the similarity of 
the processes of glanders infection in the various organic ter¬ 
ritories (farcy). In this, the bacilli meet generally but an 
insufficient resistance in its spreading march. Noth with¬ 
standing the abundance of leucocytes, the phagocytosis does 
not seem to be active, and the bacilli remain free among the 
perfectly living cell that surrounds them. The microbe, how¬ 
ever, does not meet either with conditions favorable to its 
pullulation, and though this first stage of defense is most 
commonly only very slight, in some cases it increases and 
impresses itself more strongly. Some of the cases above re¬ 
corded seem to demonstrate that infection may be interfered 
with, at least for the time being, after a new flow of migra¬ 
ting cells upon given parts. The reaction is very well indi¬ 
cated by the gathering of the leucocytes in masses, and es¬ 
pecially by the edification of the pseudo-tubercles, consti¬ 
tuted by agminated follicles. A priori , it justifies us in con¬ 
sidering as possible the localization and the destruction sur- 
place of the agents of infection from that first period. 
Very generally, lymphatic centers (media) do not offer 
sufficient resistance to the invasion, and the bacilli spread dif¬ 
fusely in the interlobular septa to reach the peri-vascular 
and peri-bronchial lymphatic spaces. The entrance of the 
bacillus into the alveolar walls takes place with difficulty, and 
numerous lobules, isolated by a thick travea, filled with nu¬ 
merous bacilli, are sometimes found perfectly intact. Some 
accidental conditions, no doubt, produce a local weakening in 
the defense, which yields to the invasion. It is also remark¬ 
able that the tubercles appear by successive growths, and 
can be admitted by the infection while it remains localized in 
the lymphatic tracts, until a change in the general condition 
facilitates the eruption by diminishing the resistance of the 
tissues. 
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