STUDY OF PULMONARY GLANDERS. 
377 
The presence of the bacillus in the alveolar walls coincides 
with the repletion of the alveoli by a fibrinous exudate ; the 
gathering of leucocytes in the middle part of the diseased 
center only taking place later. During all the first steps of 
the evolution only a very small number of microbes are found 
in the tubercle. Appearing in the middle of well defined, 
grayish granulations, it is often difficult to make out some 
bacilli, while they are in large quantity in the surrounding 
connective traveas. 
The pullulation is indicated by the central degeneration 
of the tubercle, and at that time only can the bacilli be easily 
detected by direct examination or by inoculation. The in¬ 
flammatory reaction of the tissues bring on the isolation of 
the diseased focus, but the virulency remains for a long time, 
notwithstanding the alterations undergone by the microbes, 
and it can be demonstrated by inoculation when we can find 
in the tubercle only a few granulations without any positive 
significance. 
On the side of the bronchial vessels, the bacilli produce 
the gathering of leucocytes in the lymphatic sheaths, and 
with it the inflammation of the walls. Direct observation 
shows that the penetration of round cells into the interior of 
the vessels is then possible, and also that bacilli, free or intra¬ 
cellular, penetrate, from without inward, the altered walls of 
the vessel or of the bronchia. 
The results of the introduction into the capillaries of the 
lung of the bacilli could not be foretold a priori, but those of 
the pollution of the bronchia seem evident. The microbes are 
found in great number on the surface of the inflamed mucous 
membrane in the center of an abundant exudate, which is 
thrown out under the form of a discharge. It is thus that 
the almost constant virulency of the discharge of glanderous 
horses can be explained, and not as it has been to this day 
supposed, by the opening of tuberculous centers in the bron¬ 
chioles. The bronchial alterations being independent of the 
tuberculous evolution, and subordinated only to the primitive 
invasion of the lymphatic tracts, one can conceive the viru¬ 
lency of the contents of the bronchia, even in the absence of 
all macroscopic lesions. It is theoretically admissible that an 
