462 
A. W. CLEMENT. 
find nothing but a few tuberculous areas of the size of a pea, 
and perhaps these are situated in the lymph glands. In such 
a condition, an animal cannot scatter the tubercle bacilli, 
and it might be objected that slaughter is unnecessary waste, 
but how are we to know that the tubercles, which we are sure 
exist in the body, are not in the lungs, the kidneys, the uterus, 
the testicles or even the udder? The most careful and exact 
physical examination could easily fail to elicit their presence 
at some stage of their growth. 
We know that nearly all cases of tuberculosis in cattle tend 
to advance, and that a slight depression or illness may lead 
to the rapid development of a more general tuberculous con¬ 
dition, starting from the lesion we know is present. 
The sale of an animal known to have tuberculosis, though 
ever so slightly, cannot be justified either morally or legally, 
and to keep such an animal in a herd is to harbor a foe of un¬ 
known strength. 
The writer has never seen the least bad results follow the 
injection of a quantity of tuberculin sufficient to answer the 
purposes of diagnosis. It is well known that in a tuberculous 
man an excessive dose of tuberculin may tend to aid in the 
distribution of the tubercle bacilli in the body and thus cause 
milliary tuberculosis and hasten death That an excessive 
dose will do the same in tuberculous cattle is shown by an 
experiment, in which 0.6 c.c. was administered to a yearling 
Jersey heifer that was known, from the marked symptoms, to 
have pulmonary tuberculosis. The temperature was ioi.6°. 
Following the administration of the tuberclin, a febrile reac¬ 
tion to 106.2° F. came on in nine hours. The temperature re¬ 
mained above 104° F. for six days, when the heifer died, and 
acute milliary tuberculosis of the lungs, peritoneum, kidneys, 
walls of the uterus and all of the lymph glands connected with 
the thoracic and abdominal organs was found. This result 
was evidently due to the large dose, which was six times the 
normal for an animal of the size of the subject of the experi¬ 
ment. 
The normal dose, instead of doing harm may produce good 
effects, and I have several cows under observation that gave 
