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tumor of the size of a man’s head ; here, too, was the diagnosis 
of carcinoma established .—(.Deutsche Thiet . Wockensch .) 
Acute Glanders in Man [/. Koch \.—At the meeting of 
the “Free Union of Berlin Surgeons,” on May 13, 1901, J. 
Koch reported an interesting case of acute glanders infection in 
man, which is rarely observed. The described case is of very 
great interest as it treats of a primary lung glanders, a mode of 
infection which is still disputed by some observers. Reporter 
also remarks that this case particularly is of interest to veteri¬ 
narians as it concerns their colleague, who became a victim of 
his profession. The case described by Koch is as follows : A 
county veterinarian, 45 yeais of age, became sick with high 
fever and a slight left-sided pleuritic exudate. After a few 
days a peripleural abscess formed on the left side between the 
10th and nth ribs, which was operated upon by Prof. Dr. 
Rotter. At the expiration of two more days pustules and ab¬ 
scesses made their appearance on the skin all over the body, 
which numbered about 500 in all ; at the same time the back 
of the nose reddened and widened in the form of an erysipela¬ 
tous swelling. There was a scanty purulent discharge from the 
nasal mucous membrane. With this a continual high fever was 
present, over 39 0 C. The patient died from his sufferings after 
14 days. The diagnosis of glanders was established during life 
by the characteristic pustules and abscess formations on the 
skin, by the results of the bacteriological examination, showing 
the bacilli on the dry coverglass preparate, which were taken 
and preserved from the contents of the pustules. The patho¬ 
logical condition of the lungs found on autopsy makes it very 
probable that they were the organs primarily affected. Both 
apexes of the lungs contained glandular nodules, the largest in 
the apex of the left lung, which was of the size of an apple, 
and was already infused with pus. Further, there were deep 
haemorrhagic nodules in the hyperplastic spleen present. 
Growths of the bacilli were obtained from the blood of the left 
auricle, from the pleuritic exudate of the left side, from the 
nodules of the lungs and spleen, also from the contents of al¬ 
most all the skin pustules. Two male guinea-pigs succumbed 
to the infection from inoculation of glandular material, when 
two days after the inoculation a great swelling of the testicles 
appeared (the Strauss testicle reaction). From the experiments 
on the guinea-pigs it becomes evident that a reaction can be 
obtained, not only from an intraperitoneal inoculation of the 
material, but also from a subcutaneal inoculation. Koch con- 
