HUMAN TUBERCULOSIS IS TRANSMISSIBLE TO CATTLE. 
735 
from man. The animal, which was killed after three months, 
had on the omentum and part of the stomach a great quantity 
of small, pedunculated, non-calcified growths, which had the 
histologic characteristics of pearly tubercles. He found besides 
gray miliary tubercles in the lymphnodes of the mesentery and 
a few in the liver and in the spleen. Klebs does not make 
mention of changes at the place of injection. 
Kitt obtained, by the inoculation of a calf with 20 grammes 
of juice obtained from scrofulous nodules of man, an acute tuber¬ 
culosis and death in 46 days. 
Bollinger seems to have ascertained a typical pearl-disease, 
after the inoculation of sputum of a consumptive into the peri¬ 
toneum of a calf. The lungs and the other thoracic organs pre¬ 
sented no lesion whatever. 
Crookshank inoculated a calf into the peritoneum with 
sputum, diluted with a weak solution of chloride of sodium. 
After 42 days, the animal succumbed to a pyaemia. He ob¬ 
served, besides, abscesses, containing Koch’s bacilli, also a mili¬ 
ary tuberculosis of the lungs and of the liver. 
Those few experiences show evidence that human tubercu¬ 
losis can be experimentally transmitted to the ox. This proves 
at the same time that the two tuberculoses are identical. 
The results of experimental infection by means of pure cul¬ 
tures of the human bacillus were notably different, leading to 
the most harmful conclusions regarding their practical applica¬ 
tion. 
The first experiments in this sense, dating 1898, have been 
made by Theobald Smith, of Washington. He called attention 
first to the morphologic difference between the human bacillus 
and that of cattle ; further he pointed out a still greater differ¬ 
ence in the report on their pathogenesis. 
The bacillus of pearl-disease was more virulent for the 
greater part of the animals experimented upon ; death came 
sooner, the lesions were more extensive, and they enclosed a 
more considerable number of bacilli. 
Smith inoculated 11 bovine animals of which 5 with the 
