736 
M. H. J. P. THOMASSEN. 
bovine bacillus and six with the human one. Of the first five, 
two succumbed to a miliary tuberculosis, and of the three others, 
which were slaughtered two months later, one had typical pearl- 
disease and the other two had lesions, which could be regarded 
as being of a tubercular nature. The animals had become very 
thin and shown fever during the first weeks after inoculation. 
It was not the same with the cows inoculated with cultures 
from human sputum. Slaughtered two months after infection, 
all those animals only showed local and insignificant lesions. 
Frothingham made similar experiments on four calves, with 
cultures coming from the liver of a one year old child. 
ist calf. 3 months old. Intraperitoneal inoculation. When 
tested with tuberculine 5 weeks later, the animal showed a re¬ 
action of 1.9 0 C. It was killed 6 weeks after inoculation. 
2d calf 3 weeks old. Inoculated in the same manner. 
Tested 5 weeks later, it had a thermic reaction of i.6° C. 
jd calf. 3 weeks old. Inoculated through the trachea, 
showed on being tested 5 weeks later a reaction of 2.9 0 C. It 
was killed six weeks after the infection. 
4th calf 2 months old—was similarly injected into the 
trachea. 5 weeks later a reaction of 1.4 0 C. followed the test. 
Three of those calves had a local tuberculosis in the vicinity of 
the place of inoculation, that is to say, in those inoculated into 
the abdomen, on the omentum and peritoneum and the other 
(inter-tracheal injection) in the cervical lymph-ganglia on the 
corresponding side and in the muscles of the neck. In no case 
was the tuberculosis general. I11 three calves, infected with the 
sputum of a consumptive, Frothingham found, 5 months later, 
in two, local and insignificant lesions ; the third showed no 
lesion at all. 
The author finishes with the conclusion that, apparently, 
the calf is little susceptible to the human bacillus. Is this small 
susceptibility due to a less active virulence of the bacillus or to 
a greater resistance of the animal ? This remains a fact to be 
elucidated by numerous experiments. 
In 1899, Richard Gaiser made mention of an experiment. 
