Reactions 
Rarely do side reactions occur in young children. In older 
patients local redness, induration, tenderness and perhaps a 
• 1 1 . • . A 1 1 /I. t • I * T «| 
It 
cases Tetanus Toxoid Aluminum Phosphate Adsorbed 
should be used cautiously, preferably in divided doses (e.g., 
0.1 cc. as the initial injection), which should be administered 
in essentially the same total time interval as that recommended 
for nonsensitive patients. 
Bibliography 
1. Holt, L. F.: Purified precipitated diphtheria toxoid of constant 
composition, Lancet 252: 282-285 (March 8) 1947. 
2. McComb, J. A.; Trafton, M. Z.: Immune responses and reactions 
to diphtheria and tetanus toxoids, with pertussis vaccine, aluminum 
phosphate precipitated, New Eng. J. Med. 243:442-444 (Sept. 21) 
1950. 
3. Sauer, L. W.; Tucker, W. H.: Immune responses to diphtheria, 
tetanus, and pertussis, aluminum phosphate adsorbed, Am. J. 
Pub. Health 44:784-788 (June) 1954. 
4. McGuinness, Aims C.: Review of current trends in active and 
passive immunization, J.A.M.A. 748:261-265 (Jan. 26) 1952. 
5. Press, Edward: Desirability of the routine use of tetanus toxoid, 
New Eng. J. Med. 239:50-56 (July 8) 1948. 
6. Edsall, Geoffry: Immunization of adults against diphtheria and 
tetanus, Am. J. Pub. Health 42:393-399 (April) 1952. 
7. Blattner, R. J.; Bradford, Wm. L.; et al: Report of the committee 
on immunization and therapeutic procedures for acute infectious 
diseases, American Academy of Pediatrics 1952. 
8. Love, J.; Shaul, J. F.; Margileth, A.; Martelle, R. R.: Status 
of immunization in 1954, M. Clin. North America 38:1493-1534 
(Sept.) 1954. 
9. Bradford, W. L.; Day, E.; Martin, F.: Humoral antibody forma¬ 
tion in infants aged one to three months injected with a triple 
(diphtheria-tetanus-pertussis) alum-precipitated antigen, Pediatrics 
4:711-717 (Dec.) 1949. 
10. di Sant’Agnese, P. A.: Simultaneous immunization of new born 
infants against diphtheria, tetanus and pertussis: production of 
antibodies and duration of antibody levels in an eastern metro¬ 
politan area, Am. J. Pub. Health 40:674-680 (June) 1950. 
11. La Fia, D. J.: Neuropathy caused by intramuscular injections, 
U.S. Armed Forces M.J. 3:305-308 (Feb.) 1952. 
U.S. Govt. License No. 144 • Canadian License No. 42 
LABORATORIES INC. • MARIETTA, PA., U.S.A. 
Cir. 2130 
K-0I-ED 
Printed in U.S.A. 
