70 8 
Vol. XI, No. 13 
Journal of Agricultural Research 
the fat globules were more noticeable on the peripheral cells of each 
lobule. Sheep 369 showed pronounced necrosis of the cells in certain 
areas. In sheep 367 the liver had apparently been congested, as the cells 
about the vena centralis were pushed apart. 
Kidney. —The kidney sections from all animals examined were very 
similar in pathological appearance. The lumina of the tubules, more 
particularly those near the periphery, and including the convoluted 
tubules and the loop of Henle, contained a serous exudate, showing that 
congestion had existed. There were few normal cells remaining, most of 
them having begun to break down, the portion of the cells next the 
lumen having sloughed off, leaving the edge irregular and ragged. The 
remains of such cells could often be seen in the lumina. Most of the 
blood vessels excepting the capillaries were well filled with blood, which, 
taken with the serous exudate in the lumina of the tubules, indicates a 
subacute stage of congestion. In the case of cow 699 the capillaries as 
well as other blood vessels were distended with blood. The condition of 
degenerated epithelial cells would suggest the presence of some irritating 
substance. 
While certain pathological conditions were found in the lung tissue of 
some of the cases, they were not constant enough to be considered 
significant. 
ANIMALS SUSCEPTIBLE TO EUPATORIUM POISONING 
The writers’ experiments were with cattle and sheep. Definite feeding 
experiments have been made by others, as will be shown later, which 
prove the toxicity of the plant for horses, and extracts have poisoned 
cats, dogs, and guinea pigs. So far as reported experimentation goes it 
appears that no animals are immune to the toxic principle of the plant. 
In regard to man, the definite evidence is hardly conclusive, in spite 
of a number of instances in which the plant or an extract is said to have 
been poisonous. Some of these cases are clearly apochryphal. But on 
the whole there seems to be little doubt that human beings may be poi¬ 
soned by the plant if a sufficient dosage is used. 
COMPARATIVE TOXICITY OF GREEN AND DRY PLANT 
The dry plant was fed by the balling gun to sheep 310 on January 29 
and February 9, the animal receiving the equivalent of 7.6 pounds of 
green plant per hundredweight on the first date and 13.82 pounds on the 
second. The first feeding was more than the average toxic dose of the 
fresh plant and the second feeding more than twice that amount, but 
there was no evidence of poisoning in either case. 
Two head of cattle were fed on dry material, No. 122 receiving the 
equivalent of 274.3 pounds of green plant per 1,000 pounds with no 
effect, while No. 663 received the equivalent of 294.3 pounds with only 
slight symptoms. This latter amount was nearly three times the esti- 
