A NOTE ON THE 
THERAPEUTICS OF TRYPANOSOMIASIS 
BV 
Professor BENJAMIN MOORE, M.A., D.Sc. 
M. NIERENSTEIN, Ph.D. 
AND 
JOHN L. TODD, B.A., M.D., C.M. McGill 
Thomas and Breinl* found that atoxyl would almost invariably 
drive the trypanosomes from the peripheral circulation of an infected 
animal, but, since the parasites frequently recurred, it seemed possible 
that they might exist somewhere else in the body of their host in a 
form uninfluenced by this drug. It was therefore determined to 
commence a series of experiments in which animals first treated by 
atoxyl were subsequently treated by some other drug. A variety of 
combinations have been tried. That which has been by far the most 
successful in the treatment of rats infected with Trypanosoma brucei 
is atoxyl, followed by small doses of bi-chloride of mercury after the 
trypanosomes have left the peripheral blood. Animal experiments 
are still in progress. 
This communication is made in the hope of inducing those who 
have opportunities of treating patients to try the effect of atoxyl 
followed by bi-chloride of mercury on their patients. 
Thomas and Breinl; Memoir XVI of the l.ivetpool School of Tropical Medicine. 
