25 7 
Monkeys (2). 
Two monkeys were inoculated, a baboon ( Pafio atiubis) and a Macacus rhesus. 
The baboon, inoculated intraperitoneally with 5 c.cm. of blood showing one 
trypanosome in from one to five fields, never became infected. The Macacus , 
inoculated subcutaneously with 2 c.cm. of citrated infected blood, became infected 
after an incubation period of six days. At the same time the temperature rose to 
:o5'4°. Unfortunately the further temperature chart is not of much value, as the 
monkey developed tuberculosis. The trypanosomes showed periodicity in their 
appearance and disappearance in a marked degree. The parasites were scanty at 
first, but became more numerous in the course of a couple of days and were 
afterwards present in fair numbers. The monkey died 107 days after inoculation, 
and at the autopsy the spleen and liver were found to be filled with tubercles. On 
the other hand, the lungs appeared quite normal. The lymphatic glands were not 
enlarged. 
Dogs. 
One puppy was inoculated subcutaneously with 1 c.cm. of citrated blood from 
a rat, and twelve days later trypanosomes were found in the peripheral circulation. 
The parasites have been periodic in their appearance and have never been present 
in large numbers. At the time of the first appearance of the parasites there was a 
alight rise in the dog’s temperature, but since that there have been no further 
increases corresponding to the appearance of trypanosomes in the peripheral 
circulation. The dog is quite healthy and presents no symptoms whatever. It is 
still living, 76 days after inoculation. 
Rabbits (5). 
five rabbits have been inoculated with varying doses of infected blood. The 
incubation period varies from eleven to twenty-nine days; most usually it is a out 
two weeks. The trypanosomes are periodic in their presence in the periphera 
blood and are usually rather scanty just before an increase in numbers. One 
rabbit only, showed in a marked degree the symptoms usually found in trypano¬ 
somiasis-emaciation, loss of hair with following ulceration of the skin, oedema of 
the external genitals and the base of the ears, increased secretion from the nostrils, 
conjunctivitis, haemorrhages into the anterior chambers of the eyes, panophthal¬ 
mitis and blindness. The animal also became very anaemic and there was a 
diminution in both the number of red cells and the percentage of haemoglobin- 
AH the others showed no symptoms. The disease is very chronic in rabbits, and 
lasted i 73 and 178 days in the two which died from the disease. Two other rabbits 
led early i n the disease from intercurrent affections. The fifth rabbit is s 1 
a ' lve > 76 days after inoculation. There was no marked rise of temperature when 
•be rabbits first became infected. 
At the post-mortems of the animals dying of the disease enlargement of the 
s Pleen and lymphatic glands was the most noticeable feature. The lymphatics 
" eie pale in colour and were rather firm in consistence. The spleen was conges e 
ind rather soft. 
Guinea-pigs (io). 
Guinea-pigs appear to be most resistant. The incubation period varied between 
'Cu and fifty-two days, six weeks being the average time. The disease, w en o 
5t ^hed, is 0 f i ong duration . death ensued in from 46 to 35 * days, about 9 
J being the average. Two are still alive, 76 days after inoculation. >P 
We s,i H present in both. In a few of the guinea-pigs the P ara ^ . - , 
tinuouidy present from the date of their first appearance in the P P" ^ 
maiorit 0 " Until the animal ’ s dea th- They fluctuated in numbers, how ev . I ^ 
ceil t,' penodici ‘y was noticeable. Occasionally parasites were abs 
P er al blood for long periods, e.g. 34 and 67 days. 
