2 7 8 
Two rats infected with T. gambicnse each received 32c. cm. of a • 1 percent 
solution of strychnine sulphate in five doses between the 5th and 16th November 
Parasites appeared on the 26th October. Both animals died on the 23rd November. 
In none of the above experiments were any signs of degeneration 
observed in the trypanosomes during treatment. 
(2) Strychnine sulphate followed, by atoxyl 
Curative .—Two rats each received -3c.cn!. of a -2 per cent, solution of 
strychnine sulphate on the second day of showing trypanosomes in the blood. On 
the third day, when the animals were moribund, they each received 7c.cm. of a 
•5 per cent, solution of atoxyl. One died. The second recovered and in the 
°i "' ee k rei e ’ vec l three -5 c.cm. doses of a -2 per cent, solution of strychnine 
su p a e. t s owed trypanosomes on the 17th day after their disappearance as a 
result of the atoxyl treatment, and the animal died three days later. 
( 3 ) Strychnine sulphate given in conjunction with atoxyl 
Curative. 1 he treatment of two rats was commenced on the second day of the 
appearance of trypanosomes in the blood. From the Sth to the 17th of October 
eac 1 received 3 2 c.cm. of a ‘5 per cent, solution of atoxyl in five doses and 9c.cn!. 
o a 2 per cent, solution of strychnine sulphate in nine doses. On the 16th 
.November (17 days after stopping the atoxyl treatment) trypanosomes reappeared. 
ne annua died four clays later, i'he treatment was repeated in the other (a rat 
su inocu ated from this animal at this time died in the usual way from nagana in 
a -' s 1 1 ’ bllt trypanosomes eventually reappeared and the animal died on the 
6th December. 
, treatnient of two rats was commenced 011 the third day of the appearance 
ot l. gambiense. From the 26th of October to the 23rd of November each animal 
receive 7 7 c.cm. of atoxyl in eight doses and 18-2 c.cm. of strychnine sulphate in 
wen y oses. One of the rats died on the 2nd December, the other on February 
26th, 1907; each had many trypanosomes in its blood. 
(4) Strychnine sulphate preceded by atoxyl 
^ uratt The treatment of two rats was commenced on the first day of the 
appearance of T. orucei in the blood, 7 c.cm. of a - 5 per cent, solution of atoxyl 
n ^' ln two doses > and then, on the seventh day after the trypanosomes had 
animal! ’ reataient b 3 strychnine sulphate was commenced. For a fortnight the 
on the- J„ ecei ^ e \ aiI - v 2c cm - of a -2 per cent, solution. The parasites reappeared 
trypanosome’infection^’ ^ &tOXyI WM St ° Pped ’ and both animals died ° f 
auJallnT “ e , aCh received *5 C.cm. of atoxyl on the third and fifth days of 
trvnanncmr ° ”’<cei in the blood. Two of them had no further treatment; 
each ■ . e > appeared and both died within 22 days. The two remaining rats 
davs nf 2 C ' U J}' str F cbn ’ ne solution in four doses on the sixth and tenth 
ec ion. One died of trypanosomiasis in 17 days, the other in 23 days. 
( 5 ) Strychnine arseniate 
of a -nf, ^ rats inoculated with T. brucei were given from *5 to 1-5c.cn!- 
anneannm f , Ce ” S ° Utl ° n str ychnine arseniate on the second day of the 
appearance of trypanosomes in the blood. 
the third and^f of t,le dls case was entirely uninfluenced and the animals died on 
he ^perimet. 7 ^ of the trypanosomes. In some ot 
experiments signs of degeneration of the parasites were noticed. 
