282 
The remaining four rats received 2-7 c.cm. of perchloride in four doses on the 
sixth to tenth days after inoculation ; trypanosomes were not again seen in any of 
them. One rat died (cause ?) 25 days after inoculation. The remaining three art 
still alive, 56 days after inoculation, and mice sub-inoculated from them on the 
thirty-first day are alive and have never shown trypanosomes. 
When viewed in the severest light the results of these experiments 
are distinctly encouraging. The combined treatment by atoxyl and 
mercury was given to 25 rats in advanced trypanosomiasis; all would 
certainly have died a very few hours later. Of them 13 are still 
living (after 181 to 56 days) while all the controls, which received, at 
the same time, the same quantity of atoxyl alone, are long since dead 
Experiments have been commenced in which the effect of repeated 
doses of atoxyl is compared with this combined treatment by atoxyl 
and mercury. 
The three rats in Experiments 159, 161 (see above) which died 
soon after the commencement of treatment, should probably be 
disregarded, since in these instances treatment was commenced very 
late. The cause of death of many of the treated animals is obscure. 
It must be asked whether death was ever wholly due to intoxication 
from the drugs administered. There were two recurrences of trypano¬ 
somes (Experiments 16 1 and 296). Two subinoculations in rats made 
from the treated animals dead in Experiments no and 134 are still 
alive. It therefore seems doubly doubtful whether death was in these 
instances due to trypanosomiasis. If these facts are considered our 
results become still more encouraging* 
(<£) Atoxyl followed by Donovan's solution f 
atnwl^ 6 m' IE ^ 3 1 °)■ Tight rats received 1 c.cm. of a 3 per cent, solution of 
rlnriha m W< <! dos ^ s on ,he fourth and fifth days after inoculation. Two rats died 
Donovm’if i >U « rt night - . 0,1 th e sixth, eighth and tenth days 1-5 c.cm. of 
them are tin° 'i- 10 ” WaS gIven in three doses to the remaining six rats. All of 
dav aw „i; 3 ue 44 'fays after inoculation; mice sub-inoculated on the nineteenth 
day are alive and have not shown trypanosomes. 
This experiment quite confirms those which have preceded it; it 
seems certain that such a combined treatment as we describe should 
e given a thorough trial in the treatment of human and animal 
trypanosomiasis. 
T. 6 in S P°ui npa' m ^ 3f tyP uL at P resent under observation, on T. brucei and 
complete accord 4 ,h the SfuiJobtafned^ram! 1 d °" leyS h “ V<! ” ^ “ 
t > per cent Iodide of mercury, , per cen t. of Iodide of arsenic in water. 
