It is concluded that :— 
(1) In the treatment of rats infected by Trypanosoma bructi the 
administration of atoxyl followed by mercury perchloride gives better 
results than does uncontinucd treatment by atoxyl alone. 
(2) The combined treatment should be given a careful trial in 
natural trypanosome infections of man and animals. 
( 3 ) The treatment must be commenced as early in the infection 
as possible ; full therapeutic doses of the drug must be given; fresh 
solutions of atoxyl must be employed ; c probably the mercury should 
not be given until the parasites have been driven from the peripheral 
circulation. 
LITERATURE 
1. 
2. 
3 - 
4 - 
5 - 
6 . 
7 - 
8 . 
9 - 
Thomas and Breinl. Liverpool School of Tropical Medicine. Memoir XVI, 
1906. 
\ an ( AMi'hNHOUT. Bulletin de l'Academie Koyale de Medicine de Belgique. 
1907. 
Breinl and Todd. British Medical Journal, January 17th, 1907. 
avera.v. Bulletin de l’Academie de Medecine, 26th February, 1907. 
Moore, Nierenstein and Todd. A note on the Therapeutics of Trypano- 
somiasis, Annals of Tropical Medicine and Parasitology, Vol. 1, No. 1, 
C ‘ R - de 1Acad - Sciences T. CXL, 17th April, .905, p. 108; also 
Ehrlich and Shiga. Berl. Klin. Wochenschrift, 1907, N 13/17. 
Meyer”.' Ther&pie der ^egenwart, Vol. 48, p. .29 (Reported by N. 
‘?T* anfl ^ IC0LLE > anci Albert. Annales de l’Institut Pasteur, 1907, 
Deutsche med. Wochenschrift, 17th Nov., 1904' 
Wendelstadt and Fulmer. 
N - 47 . P- 1711. 
, Chemother apeutische Trypanosomenstudien, Berliner Klinische 
uresent ’ , . 9 ° 7 .’ N °' 9 ' 12 ’ P- 33 - This paper was received after the 
present communication was completed and in the printer's hands. 
parasite 3 of a S ^ , ' VIN ' Moo ® Ei Preliminary note on the life history of the 
parasite of Sleeping-sickness,” Lancet, 3rd April, 1907. 
intravenously*(1). " K "’ Wh ° " ta *' e the necessary precautions, atoxyl is best givei 
