295 
Mult Female forms. 
Adult female parasites, makrogametocytes, are rather less 
numerous and larger than adult male parasites. Their general 
characteristics, as outlined above, are: deeply-staining endoplasm, 
containing more or less numerous chromatophilic granules and small 
clear spaces — “ vacuoles ” ; and small amount of nuclear material, as 
compared with the male parasites. The average measurements of the 
most usual type of makrogametocytes (figs. 65, 67) are:— Total 
length, 55'6//; endoplasm, length 20-3^, breadth 9'S^i. Slender forms 
igs. 62, 73) in which these measurements were 6 yifx, 22 and 8'5^t 
respectively, as well as stumpier forms (fig. 69) measuring 47/i, 16^, 
and 14 n, were constant types. Much effilated forms (fig. 72) are rare. 
They occur most frequently in the thickest parts of our blood smears. 
In the most usually seen form (fig. 67) the nuclear material 
forms a diffusely-pinkish area (chlamydoplasm ?), usually without 
a sharply-defined limit, but possessing a definite oval contour. In it, 
or immediately adjacent to it, is the more or less deeply-staining, 
often granular, hlepharoplast ( ?). Adjoining the blepharoplast an 
oval, more lightly stained area—the vacuole—can usually be 
distinguished (fig. 73). Other less conspicuous, dense, chromatic areas 
may also occur in the chlamydoplasm (fig. 66). The phenomena 
attending line formation in the female (figs. 62, 63, 64) seem to be 
analogous to those described in the male and in the young forms; 
because of the darkly staining endoplasm it is, however, very difficult 
to follow them. 
No changes were observed in the nuclei of the female cells which 
s eem peculiar to them. For this reason no special description is 
§‘ v en of them ; the few drawings reproduced indicate the 
resemblance between the nuclear changes in the two sexes. I he 
Cf| arse alveolar structure of the endoplasm, common to all forms of the 
Parasite, is particularly defined in the makrogametocytes. I he curved 
outlines of the alveoli, merging into one another, often give the appear- 
,lnce °f wavy blue lines running through the parasite. The gianules 
var y greatly in number and size. There may be as many as fifty. 
W are almost dust-like ; usually they are larger, and may measure 
‘Iniost -5yx in diameter. They frequently occur in pairs and seem to 
' K placed superficially in the parasite. They often lie in lines along 
'' ne ta 'nt striations of the ectoplasm. Of the origin and nature of 
