DISEASES OF BLOOD AND BONE MARROW 101 
tissue in their deeper parts. Arteries quite normal. Atrophy 
with regeneration. 
Liver. — Capsule and interstitial parts on whole normal. Perilob- 
ular fibrous tissues largely missing, but where remaining show an over- 
growth occurring in peculiar zonal arrangement and of old adult almost 
hyaline type. Its fibres are often arranged strikingly in whorls. Bile 
ducts, arteries and veins quite normal. Parenchymal cells of normal 
size, finely granular, prominent normal nuclei and contain small 
quantities of finely granular, golden brown pigment not really as 
abundant as commonly seen in severe anemias. Blood capillaries 
narrow, contain small quantities R.B.C., and Kupffer's cells very fre- 
quently contain fine granules like those of parenchymal cells but of a 
greener tint. In a few isolated areas parenchymal cells distinctly more 
swoUen than others and many show disintegration of nucleus. Hemosid- 
erin pigmentation. Perilobular fibrosis. Slight local cloudy swelling. 
Kidney. — Capsule smooth, interstitial fibrous tissue of organ proper 
highly fibrosed in peripheral parts, but slightly in deeper. No 
lymphocytic infiltrations anywhere or sclerosis of vessels. Tubular 
epithelium highly atrophic in subcapsular regions where tubules are 
narrow. In deeper parts epithelium is at times so swollen as to occlude 
lumina, where they are coarsely granular and occasionally show some 
karyolysis, a pink hyaline or finely granular material. Tufts never 
show fibrosis, normal size. Bowman's capsule heavily thickened. Chronic 
diffuse nephritis (subcapsular type). 
Spleen. — Slightly hyalinized capsule, normal thickness. General 
reticulum of pulp slightly fibrosed and poor in lymphocytes. Sinuses 
broad, crowded with red blood cells, but only small numbers of lympho- 
cytes. Coarse granular blood pigment abundant, showing greenish 
cast on focusing. Malpighian follicles nonnal size, slightly fibrosed, 
and in several instances show a deposit of smooth pink material 
between cells. Congestion. Fibrillar fibrosis. Hemosiderin pigmenta- 
tion. Local amyloid infiltration. 
Adrenal. — Organ appears normal in all respects save for pi'esence 
of a few small irregular areas of calcification in medulla. These occur 
apart from any recognizable necrotic or fibrous areas. In one place one 
appears to lie within lumen of blood vessel. No fibroses or special 
congestions anywhere in organ, and cells show normal details and 
normal numbers of vacuoles. Calcareous infiltration of medulla. 
Stomach. — Muscular tunic normal. Submueosa thin, has densely 
arranged bundles of smooth, pink character. Mucosa distinctly thinned, 
shows comparatively few regions holding acid cells, consisting for most 
part of peptic type of gland. These are short and of broader calibre 
towards lumen than deeper, suggesting a hyperplasia of luminal por- 
tions; stroma richly infiltrated with lymphocytes, not fibrosed or con- 
gested. Epithelium of crypts has rarefied appearance, shows no special 
degenerative changes. Chronic atrophic gastritis. 
