DISEASES OF BLOOD AND BONE MARROW 103 
tibia and femur gelatinous and red, not slightest trace of yellow. Blood 
films from heart's blood show poikilocytosis and anisocytosis ; only one 
nucleated red. 
Microscopic Notes. — Heart has torn but normal pericardium. No 
abnormalities of interstitial tissue or vessels. Fibres of normal width 
but show transverse markings irregularly since cytoplasm becomes 
hyaline and swollen in many places along its course. Nuclei prominent, 
slightly pyknotic. Zenker's Hyaline. ' 
Bone marrow consists of a matrix of granular or fibrillar mucoid tis- 
sue within the delicate reticulum of which highly developed capillaries are 
placed, together with stellate spindle and sealring cells. In a few 
places only are myelocytes recognizable and then in decreased numbers. 
Plasma cells sometimes found containing much blood pigment. 
Liver. — Capsule normal; perilobular fibrous tissue only slightly 
overgrown, moderately infiltrated with lymphocytes and heavily with 
blood pigment. Arteries, ducts, veins, normal. Parenchymal cell a 
little smaller than normal with nuclei of normal type, and crowded with 
fine granules of blood pigment. Latter lie in usual pericanalicular posi- 
tion. Blood capillaries narrow, moderately congested and Kupffer's cells 
also contain abundant pigment granules. 
Thyroid. — Interstitial framework shows no fibrosis or cellular infil- 
trates. Blood vessels normal. Acini fairly uniform in size, none ever 
attaining large proportions, but some being distinctly below normal. 
They are uniformly filled with a very pale pink hyaline material which 
in some way gradually increases in color intensity toward one side, 
attaining in a few examples usual intensity of colloid. Lining epithelium 
is low cuboidal, shows no special hyperplastic features or atrophy. 
Kidney. — Capsule normal. Interstitial tissue normal. Blood vessels 
slightly congested. Tubular epithelium granular, disintegrated and fre- 
quently contains numerous fat globules and obscured nuclei. Lumina 
of about normal size containing variable quantities of pink granular 
detritus. Glomerular tufts normal in size and appearance. Subcapsular 
space and Bowman's capsule normal. 
Adrenal. — Capsule and pericapsular tissue normal. Parenchymal 
cells throughout poor or practically free of vacuoles, such appearing 
in only limited portion of pars vesicularis. Interstitial framework 
and vessels normal. Structure of columns in pars vesicularis is peculiar 
in that they extend quite to capsule with no intervening pars glomerulosa, 
and again in that most peripheral parts are expanded at times showing 
a lumen, while deeper parts show broad cells extending fully across the 
column. Pars reticularis contains no pigment and medullary cells 
quite normal. Skeletal muscles show comparatively few fibres with 
transverse markings. Most are swollen, hyaline, lumpy, and have 
pyknotic nuclei. Interstitial parts show no inflammatory change. 
Tissues treated by Prussian blue test for iron. Kidney, adrenal, heart 
found to contain none. Spleen, liver contain abundance. That in spleen 
responds to test showing that it is all iron containing. Two kinds of 
