THE DUCTLESS GLANDS 327 
This rather diversified group of pathological lesions 
would warrant one to expect a notable number of 
instances of disease observed during life, suggesting that 
the thyroid was at fault ; such, however, is not the case. 
In the first place, no case of exophthalmic goitre, as the 
symptom complex is knowai in man, has been observed, yet 
the anatomical alterations, hyperplasia mthout colloid, 
and with papillary or solid adenomatoid character, are 
abundantly represented. For the pathologist to accept 
a case as toxic goitre I w^ould ask evidence of enlargement 
of the heart and perhaps in addition degeneration of the 
myocardium. The animal showing the closest resem- 
blance to the disease in man was a Raccoon-like Dog 
(Canis procyonoides) whose history and notes are given 
in brief. 
Raccoon-like dog {Canis procyonoides) 9. Acute hemorrliagic 
splenitis. Acute fermentative gastritis. Subacute catarrhal enteritis. 
Acute general infection. Hypertrophic cirrhosis of liver. Chronic 
interstitial nephritis. Hypertrophy of heart with acute myocarditis- 
infiltrative and parenchymatous. Chronic lymphadenitis with acute 
exacerbation. Epigastritic and gastric venous stasis. Nodular adenoma- 
tous goitre. The right thyroid is lower, both measure 4x3x2 cm., are 
soft, resilient with dense gray capsule. Section shows cysts filled with 
blood separated by pale septa of soft tissue of varying thickness. One 
similar mass under angle of jaw seemed like a lymph node but on sec- 
tion is like thyroid. Parathyroids not found. Pleurae negative. Lungs 
are gray, collapsed except lower half of lower lobes which are slightly 
emphj'sematous and edematous. No consolidations. Pericardium con- 
tains about 3 cc. clear, colorless fluid. Epicardium is glistening, trans- 
parent and pale. Heart muscle is soft flaccid, pale mottled gray-brown. 
All chambers are distended with mixed clot. The coronary muscles and 
columnas are mottled brown and gray. The tips at insertion of chordge 
are pale. Streaks of gray run through muscles. One area 1x2 em. 
of softening found in middle of left auricular muscle. Aorta nega- 
tive. The liver is enlarged, surface rough and irregular, edges rounded 
and uneven, consistency firm and tough, color mottled deep red-brown. 
Section surface glistening, moist, granular, opaque. Lobular markings 
not lost but obscured. Connective tissue lines not clear but surely 
diffuse in lobules. Scars on surface leading to definite connective tissue 
strands about vessels and irregularly placed. Gall-duct patulous 
with limpid bile. Spleen is well forward in front and below stomach. 
It is much enlarged, soft, tough, has a smooth, tense capsule. Section 
