THE DUCTLESS GLANDS 329 
crease of connective tissue nuclei. No pigmentation. There are several 
areas of round and polynuclear cell infiltration and one distinct abscess 
in section. The perivascular tissues are edematous. Muscle fibres are 
large and wide. Thyroid made up largely of slightly enlarged acini in 
most of which a slightly eosin-stained hyaline collection is found. 
There are a few cysts containing a thrombus and hemorrhage. There 
are no typical colloid cysts. Some sears from old hemorrhages may be 
seen. There is much free blood in and between acini. Blood pigment 
free and in granule cells is abundant. Some acinus cells show fat drop- 
lets. Lung shows old interstitial tissue increase especially about vessels 
and a few scars, some of which are forming cartilage. These are deeply 
encapsulated. Mesenteric lymph nodes show trabecular thickening with 
active connective tissue formation which is also present about follicles 
and along edges of chords. Follicles lack germ centres, solidly lymphatic. 
About them and in and along chords are many tissue cells some of 
Maximov type and a few eosinophils. Many of these and endothelial 
cells are phagocytic of red blood cells. (Fig. 32.) 
Just at the time of completing this book another case 
strongly resembling exophthalmic goitre in man was 
encountered in a Gray wolf {Canis lupus). This animal 
had a history of enlarged neck and enlarging abdomen for 
about six months. His appetite and discharges remained 
about normal but weight was lost and activity reduced to 
a minimum. Attempts at remo\dng the fluid believed to 
be in the peritoneum, by the use of diuretics, failing and 
the beast being in such poor shape, he was killed. An 
enormous adenomatoid goitre, concentric hypertrophy of 
the heart, passive dilatation of all cervical and thoracic 
veins, passive congestion of the liver and congestion of 
the portal area were autopsy diagnoses. It will be 
noted that no exophthalmos and nervousness were 
observed during life. 
Bone disease and atheroma are at times associated 
with thyroid insufficiency in man. The former, aside from 
osteogenesis imperfecta of cretinism, occurred only once 
in a carnivore and once in a marsupial. There is but 
one case of atheroma among the sixty cases of thy- 
roid disease. 
The reaction of the avian thyroid in its hyperplasias is 
somewhat different from that of the mammalian. The 
22 
