THE DUCTLESS GLANDS 333 
Tumors. 
True malignant hyperplasias of the thyroid epithelium 
in man are being more thoroughly studied in recent times 
so that similar lesions in the lower animals gain interest. 
The notes given below are of value as individual observa- 
tions only, but since three were in carnivores, another 
indication is at hand of the vulnerability of this order. 
One of the cases is admitted upon diagnosis alone, the 
slides and records having been lost, but since the deter- 
mination was made by Dr. C. Y. White, I am satisfied to 
accept it. The four of which notes are at hand are 
as follows : 
Raccoon-like Dog {Canis procyonoides) 6. Adenocarcinoma sarco- 
matodes. Metastases to liver and lungs. Fatty degeneration of liver 
and kidney. Acute diffuse splenitis. Submucous hemorrhages in 
stomach. At level of thyroid cartilage on each side and removed 1 cm. 
from same is a rounded encapsulated nodule measuring 2.5 x 2 x 1 cm. 
Portions are hard, others fluctuate suggesting cystic degeneration. Below 
these nodules are two bodies also bilateral, evidently lobes of thyroid, 
each measuring 5 x 2,5 x 2.5 cm. They are firm with some foci of 
cystic softening. From a ruptured cyst of the right lobe grumous, red, 
malodorous material exudes. Peripheries of such cyst show greenish 
discoloration. Bodies as a whole are greenish black in color. They are 
well encapsulated, do not meet in midline but are joined at lower pole 
by firm, apparently colloid, material. All through lung especially under 
pleura there are dark red, rounded, firm, well circumscribed foci measur- 
ing 2-8 mm. diameter. They project markedly on pleural surface. No 
capsule can be made out. Upon incising they have lighter red centres 
and deeper peripheries. They cut with resistance and have no inclination 
toward a wedge shape. Surface is for most part smooth except where 
tumors are present. Organ is soft and distinctly yellow. All portions 
of liver contain rounded and irregular nodules, some deep, others super- 
ficial. They vary in size from 2 mm. to 3.5 cm. diameter. No capsule 
can be made out, yet they are circumscribed. The central portions of 
larger nodules are dirty gray and friable. Peripheral parts dark red. 
Smaller lesions are solid red and of fleshy consistency. Spleen is deep 
dark red, homogeneous. Histological section of thyroid shows firm, 
old, dense capsule very irregular in thickness seemingly on account of 
the penetration of the enclosed tumor cells. Such infiltration gives the 
inner outline of capsule a very irregular, bizarre appearance, and at 
times thins the capsule until it is reduced to nil. In one place the 
tumor elements appear outside the capsule at a point where a large 
vessel is apposed to outside capsule. The appearances within this cap- 
