THE SKELETON AND ITS JOINTS 355 
cases of osteomalacia and thirty-four of rickets, no 
abnormality has been observed in ovary, testes or 
adrenals except for moderate congestions. Two cases 
were associated with pancreatic disease, once acute, once 
chronic. The thyroid body has been found to have been 
definitely abnormal only once — secondary hyperplasia 
with colloid in a carnivore. In the Primates this body was 
frequently congested and has shown small colloid cysts 
but was not uniformly enlarged or atrophic. As a thera- 
peutic measure I have administered adrenalin to two 
monkeys, one for a few weeks, one for nearly six months ; 
this treatment was without any perceptible effect upon 
the process. 
Dr. Corson-White has, by the study of some cases 
during the life of the monkey, confirmed the decreased 
alkalinity of the blood in connection with the increased 
output of calcium in the feces and urine. 
Since the explanation of the disease by blaming the 
ductless glands has failed. Dr. Corson- White has under- 
taken a study of the diet given our monkeys to see if any 
fault in it were a part of the etiology. Analysis of this 
diet (see list page 426) computed from Atwater's table, 
and by actual analysis of the amounts of food consumed 
by the animal in four four-day periods, gave : 
1. Protein — low in quantity and poor in quality ; espe- 
cially low in phosphorus content. 
2. Fat — ^very low. 
3. Carbohydrate — very high, almost eleven times the 
value of all other ingredients. 
4. Ash — decidedly low and predominatingly acid. 
Further analysis of this ash showed a trace only of cal- 
cium and phosphorus and iron and only a small amount 
of sodium; potassium, sulphur and magnesium were 
slightly higher. 
5. Vitamines A, B, C, were present in extremely small 
amounts — A was exceptionally deficient, and in the 
rations of some days was entirely lacking. 
