548 DISEASE IN WILD MAMMALS AND BIRDS 
conjunctival sac and given a subcutaneous dose of old 
tuberculin. Another set received 1 per cent, old tuberculin 
into the conjunctivae and the usual subcutaneous dose. 
Although all these monkeys gave a temperature reaction 
only one gave a conjunctival reaction. Fearing that the 
two tests simultaneously might be an unfair trial, another 
poor specimen was given an eye test which resulted 
negatively; a later subcutaneous test and autopsy 
revealed the disease. Because of these experiences and 
the fear that any reacting conjunctivse might become sec- 
ondarily infected from the uncertain personal, hygiene of 
the beast, we decided to omit this method and rely upon 
the temperature test. 
Pathological Effects of the Injection of Tuberculin. 
It is generally believed that tuberculin injected into 
tuberculous animals, in doses large enough to produce a 
marked reaction at the site of disease, may stimulate the 
process to growi:h and spread and that certain parenchym- 
atous organs in such bodies undergo degenerative 
changes. We can give little information concerning the 
first point because known infected animals have not been 
sacrificed during the test and we are not informed of the 
degree of morbid lesion in those dying, since we had no 
previous knowledge of its existence. 
An interesting and practically useful observation has, 
however, been made upon the kidneys of several monkeys 
dying shortly after tuberculin injection. It consists in a 
marked cloudy swelling of the renal epithelium and a con- 
gestion or even thrombosis of the glomerular capillaries, 
accompanied sometimes by increase of nuclei in the tuft 
and by amorphous material in the space of Bowman. 
Grossly such kidneys are but little changed, albeit the 
cortical zone may be dull and opaque and swell out 
slightly on section ; very occasionally bloody streaks may 
separate the cortical and medullary striae. In a few kid- 
