Apr. is, 1921 
Carbon Tetrachlorid for the Removal of Wonus 
163 
higher than the other two substances. The relation of these facts to the 
use of carbon tetrachlorid as an anthelmintic are pointed out in a consid¬ 
eration of the anthelmintic studies in this paper. A final point to be noted 
is that pure carbon tetrachlorid must be used in testing. The drug may 
carry carbon bisulphid as an impurity, and Dr. Couch, of the Pathological 
Division of this bureau, tells me that phosgene, carbonyl chlorid, may be 
present under certain circumstances. This latter substance was used as 
one of the poison gases during the late war and has a marked depressant 
action on the heart. 
ANTHELMINTIC EXPERIMENTS 
In the experiments on dogs reported in this paper, the technic is the 
same as that given in previous papers by the writer alone or in collabora¬ 
tion with other investigators ( j-ii ). The animals were given anthel¬ 
mintic treatment, and all feces passed were collected once a day for 3 to 
6 days, screened, and the worms passed were identified and counted up 
to the time of death. The animals were killed by illuminating gas, 
chloroform, or shooting through the head; and the worms present post 
mortem were identified and counted, the gross pathological conditions 
present post mortem being noted with especial reference to conditions due 
to the drug administered, allowance being made for the lesions due to the 
agent used in killing the animal. The protocols are abbreviated to the 
following form: Dog’s number; dose in terms of mils (cubic centimeters) 
per kilogram, abbreviated to m. p. k.; worms passed daily, first day being 
the first day after treatment, that is, for the first 24 hours following treat¬ 
ment; post mortem, abbreviated to p. m. and showing the worms 
present; percentage of efficacy against kinds of worms present. 
CARBON TETRACHLORID ALONE 
In the following experiment carbon tetrachlorid was administered in 
capsules, followed immediately with 30 mils of castor oil, after the 
animal had fasted 18 hours. 
Dog 367; 0.3 m. p. k.; no worms in 6 days; p. m., 7 whipworms; o 
per cent vs. whipworms. 
In the following experiments carbon tetrachlorid was administered in 
capsules after the animal had fasted 18 to 24 hours, but without purga¬ 
tion. 
Dog 381; 0.3 m. p. k.; 16 whipworms second day, 1 whipworm fourth 
day; p. m., 116 whipworms; 13 per cent vs. whipworms. 
Dog 386; 0.3 m. p. k.; 6 ascarids first day; p. m., 1 whipworm, 15 
Dipylidium sp.; 100 per cent vs. ascarids, o per cent vs. whipworm and 
Dipylidium sp. 
Dog 3 8 7 ; 0.3 m. p. k.; 4 hookworms first day, 1 whipworm second 
day; p. m., 5 whipworms; 100 per cent vs. hookworms, 17 per cent vs. 
whipworms. 
