Apr. is, 1921 
Carbon Tetrachlorid for the Removal of Worms 
167 
per cent; no ascarids were present. The mixture appears to be as effective 
as carbon tetrachlorid alone in the same dose; a larger series of experi¬ 
ments might show that it was more effective. 
CARBON TETRACHLORID PLUS CHENOPODIUM 
In order to ascertain whether oil of chenopodium could be added to 
carbon tetrachlorid with any increase in anthelmintic efficacy, a solution 
was made up at the rate of 3 mils of carbon tetrachlorid to 1 mil of cheno¬ 
podium. This solution was administered in capsules in dose rate of 0.3 
m. p. k. after fasting and without purgation, as follows: 
Dog 419; 1 hookworm and 2 whipworms first day, 109 hookworms, 
8 ascarids, and 61 whipworms second day, 1 whipworm third day, 1 
whipworm fourth day; p. m., 12 whipworms, 1 Dipylidium sp.; 100 per 
cent vs. hookworms and ascarids, 84.5 per cent vs. whipworms, o per 
cent vs. Dipylidium sp. 
Dog 421; no worms in 8 days; p. in., 92 Dipylidium sp.; o per cent vs. 
Dipylidium sp. 
It appears from the foregoing that a mixture of carbon tetrachlorid, 
3 parts, and chenopodium, 1 part, given in capsules at the rate of 0.3 
m. p. k. to 2 dogs, removed no hookworms and left none, an efficacy of 
100 per cent; removed 8 ascarids and left none, an efficacy of 100 per 
cent; removed 65 whipworms and left 12, an efficacy of 84.5 per cent; 
removed no Dipylidium sp. and left 1, an efficacy of o per cent. The 
mixture is, therefore, as effective as carbon tetrachlorid alone in the 
same dose; a larger series of experiments might show that it was more 
effective. 
In the following experiment, the above-mentioned mixture of carbon 
tetrachlorid and chenopodium was given at the same rate, 0.3 m. p. k., by 
means of a dose syringe to a dog that was too savage to dose successfully 
by means of capsules: 
Dog 423; no worms in 8 days; p. m., 7 hookworms, 1 whipworm, 40 
Dipylidium sp.; o per cent effective vs. hookworms, whipworms, and 
Dipylidium sp. 
The complete failure of the treatment in this case, in contrast with the 
excellent results obtained in the case of dog 419, where the dose was given 
in capsules, must be attributed to the difference in the mode of admin¬ 
istration. By the use of the dose syringe, part of the dose is lost in the 
syringe, part by evaporation from the mouth and by slobbering, and there 
may be other factors present that modify the result. 
SUMMARY 
An inspection of the results obtained in the foregoing experiments 
with carbon tetrachlorid shows that when given in capsules at a rate of 
0.3 in. p. k. it constitutes a very effective treatment for hookworms in 
