27 
merit de la maladie du Sommeil.’ (Rapport presente au XIV Congr^s 
Intern. d’Hygiene et Demographic. Lisbonne, 1907). 
His results with atoxyl are not very good. Out of 29 cases, 22 
died from trypanosomes. Seven are still alive and of these only 
two are in good health. 
Kopke used very large doses of Atoxyl (one gramme in one 
injection). Out of 29 cases, six had eye lesions which were 
diagnosed as atrophy of the optic nerve, and were certainly due to the 
over-doses of atoxyl given. 
Thiroux et d’AnfrevillE, ‘ La maladie du Sommeil au 
Senegal,’ record. ‘ trois cas traites, guerison dans un cas.’ Rapport 
de Laveran, (Bull. Acad. Med. Seance de 26 fev. 1907). 
Hollebeke, ‘Traitement de la trypanosomiase par 1 atoxyl. 
Notes cliniques et therapeutiques,’ (Bull. acad. roy. de med. de 
Belgique, Vol. XXI, 1907), treated eight Europeans for trypano¬ 
somiasis. Gave daily injections of 0*2 gramme of Atoxyl. Never 
observed any eye-symptoms. After six months, he stopped the 
treatment and the same improvement continues. He considers his 
cases as cured. 
JakimOFF, ‘ Zur Atoxylbehandlung der experimentellen Dourine, 
(Deutsche, med. Wochenschrift. 1907. No. 16). cured white rats 
infected with Dourine by Atoxyl. 
Martin, in a paper entitled ‘ Maladie du Sommeil. Cinq 
nouveaux cas de trypanosomiase chez les blancs. Essais de traite¬ 
ment,’ (Ann. de Inst. Past. Tome XXI, Mars, 1907), states that Atoxyl 
has a very noticeable action on the trypanosomes, which disappear 
from the blood, as in malaria the parasites disappear under quinine 
treatment. Concerning whether or not a permanent cure has been 
effected, he states that it is impossible to say anything as the time 
was too short. 
Cook, at a meeting of the Society of Tropical Medicine and 
Hygiene, Oct. 26, 1907, discussed the question of sleeping sickness 
in Uganda, and stated that Atoxyl was by far the best drug for the 
cure of the disease that had yet been tried, and ‘ that it was greatly 
to the credit of English investigators that an Englishman, Thomas, 
of Liverpool, first applied it to the treatment of sleeping sickness.’ 
UhlenhuTH, ‘ Demonstration von mit Atoxyl behandelten 
Dourinekaninchen ’ (Deut. med. Wochenschrift, 1907, No. 30); 
