28 
Uhlenhuth, Hubener and Woithe, ‘ Ex{>erimentelle Untcr 
suchungen iiber Dourine mit besonderer Bcrucksichtigung der 
Atoxyl behandlung ’ (Arb. a. d. Kaiserl. Gesundhoitsamte, Bd. XXVII. 
h. 2, 190;); 
Uhlenhuth. Gross and Bickel, * Untersuchungcn ul)«’ dir 
Wirkung des Atoxyls auf Trypanosoinen und SpiriKrhaten ’ (Deutsche 
med. Wochenschrift, 1907, No. 4), give the results of treatment of 
experimental animals infected with T. equiperdum (Dourine) with 
Atoxyl («:) preventive, {b') curative. Preventive results were not very 
encouraging. They were able to drive the Dourine parasites out of 
rabbits, rats and mice, and to keep the animals alive. The authors 
do not state whether it is a definite cure, as the time of observation 
was too short. 
n-nriich s experiences with Atoxyl in experimental treatment are 
very favourable. He was able to prove that the different trypano¬ 
some strains become after a time resistant to the drugs, and he got 
the festen strains; an Atoxyl resistant, a para-Fuchsin resistant 
strain, which did not even in sub-inoculation react to the drug. 
The Atoxyl resistance may partly explain the unfavourable results 
in some cases of sleeping sickness, as described by Kopke and 
Broden. 
To Fourneau (Jounial Phar, et Cliim., Oiemc serle, T. XXV. 
I pnl, 190/) is due the credit of showing that, chemically, atoxyl 
Isr!, “r T been synthet.zed us long ago as 
63 by Bechamp m the early days of the synthesis of aniline colours. 
fuchs,n bemg produced in abundance at the same time. Bechamp 
supposed that he had in hand an anilide of ortho-arsen.c ac.d 
- Todd, 
stated that Atoxyl \ls\hi sodhim .. H '"r 
acid, with four molecules of wnt ^ 
Moore, Nierenstein and Todd (Brchr*°"l 
Nos. 5-6, 1907, pn ,00 „■ m i"'°-^bem,cal Journal. VoL II, 
ONaOH,3H,0, and they ifd :ndtpe:dln™“'“ 
that the arsenre radicle was un.ted direCly^toX "ng sTcer: 
