suggest the use of Sodium antimonyl tartrate. Out of 25 rats which 
have been treated with this substance, 23 had no relapses from 25 to 
26 days. No local disturbances are caused by the injection of the 
drug into rats, in doses of up to 0*5 centigramme. 
In the hands of one of us (A. H.) Sodium antimonyl tartrate has 
not given the good results Plimmer and Thomson described A 
fairly virulent strain of T. equiperdum was used. Out of twelve rats 
treated with two to four injections of o'25 r.c. of a I per 
cent, solution (o’35 of the same solution was the fatal dose) 
only one rat which was treated during the incubation period 
of the disease is still alive, all the others having died ten to 
fifteen days after the last injection of the drug, their blood 
swarming with parasites. One horse infected with a strain 
of cattle trypanosomes, brought back from the Congo, has been 
under treatment since December 9th. having received five intra¬ 
muscular injections. loc.c. of a i per cent, solution of Sodium 
antimonyl tartrate. It is still showing parasites in a very small 
number from time to time ; they were seen even three days after 
the last injection. The local effects of the drug in rats are very 
severe : necroses and sloughing. 
The parasites, however, disappear very rapidly indeed, generally 
speaking more so than after a corresponding injection of Atoxyl. 
But notwithstanding our results, we consider that the introduction 
of another metal (Antimony) belonging to the same group as Arsenic 
IS a further progressive step in the treatment of sleeping sickness, 
and IS moreover very suggestive. 
