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MY EXPERIENCE OF TRYPANOSOMIASIS 
IN EUROPEANS AND ITS TREATMENT 
BY ATOXYL AND OTHER DRUGS 
BY 
Sir PATRICK MANSON, K.C.M.G., F.R.S., &c. 
{Received January 23rd, 1908) 
In view of the recently recorded experiences of Campenhout, 
Broden, Kopke, Koch and others in the treatment of human 
trypanosomiasis, especially in negroes, by atoxyl, it may not be 
inopportune if I gave some account of my experience of this disease 
in Europeans, and of atoxyl and other drugs in its treatment. 
My experience of trypanosomiasis in man extends to seventeen 
cases—seven negroes, ten whites. The negroes, who had been 
brought to Europe for purposes of clinical study, and because they 
had already entered on the terminal phase—sleeping sickness of 
the infection, all died. They did not have the benefit of Thomas’s 
important discovery of the therapeutic value of atoxyl. I shall not 
allude to them further. 
Of the ten whites, three of the cases have been recorded already 
by myself and others. For the sake of completeness I shall briefly 
mention here these three cases, along with the seven unrecorded 
cases, giving them along with the latter in the order in which they 
came under my observation, but referring the reader to the medical 
journals for details. 
I.—Mrs. H. M. was first seen by me on July 17th, 1901. She was 
then 40 years of age, and had resided on the Congo for two periods 
of two years and one year respectively. During the latter period she 
had suffered much from fever. Being pregnant at the time she dame 
home, arriving in England in April, 1901. She had fever all the way 
home. A week after her arrival her child was bom, and from that 
time till the date of her visit to me she had attacks of fever lasting 
for three days at a time and occurring at intervals of seven days 
with considerable regularity. She also suffered with pains in her 
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