or malarial in nature. On the discovery of the malarial infection 
quinine was given systematically at definite intervals as well as 
atoxyl, and was now very well borne. 
At first the atoxyl was given in one grain doses (lO per cent, 
solution) hypodermically every third day. It was gradually raised to 
2’3 grains, beyond which, after not a few attempts, it was impossible 
to push it. Every time a 2'5 grain dose was given, violent and 
alarming gastralgia ensued. The 2'3 grain doses of atoxyl, and 
occasional io grain doses of quinine were therefore steadily 
persisted with. 
Under the persevering use of these drugs and with careful 
nursing the patient slowly improved, the erythema, the adenitis and 
the dysentery disappearing. When the weather became milder, and 
he could walk about, the patient was removed to a healthy and 
bracing place in the country, where I saw him from time to time. 
There the febrile attacks became milder, returning at longer intervals, 
the trypanosomes being found only occasionally in the blood and 
never in large numbers. In the course of the summer of 1906 he 
suffered at one time from severe dental neuralgia, and twice from 
smart attacks of orchitis. Notwithstanding this, general improve¬ 
ment continued. He spent the winter of 1906-7 on the high Alps, 
where, with the exception of a brief but painful attack of what 
might have been erythema nodosum in one leg, he kept quite well 
and gained strength. I saw him again on July 25th, 1907, and noted 
that ‘he had had no fever since 21st February with the exception 
of that attending a slight cold in May (temperature 101°). Weight 
g-J- stone — the highest he has ever been in his life. Feels quite well.’ 
He refused to consider himself any longer an invalid. A 
situation was offered to him in South America, my consent being a 
condition of the appointment. This I promised provided injection 
of his blood into monkey, rat and guinea-pig proved negative. These 
injections were made in August. All the animals were alive and free 
from trypanosomes in October when he sailed for South America in 
the best of health, promising to keep up the atoxyl injections for 
another year and to report progress. 
A letter just received and dated 31st December, 1907, stated that 
‘ he is very well indeed,’ and ‘ to see him now no one would think 
he had ever had an illness.’ 
