2 .^ 
favourably to only a few agents, of which arsenic is the only drug 
which seems to exert a more than transient action. 
‘ (2) That the greater the amount of arsenic introduced into the 
system of the animal the greater and more permanent the effect on 
the parasite. 
‘ (3) That arsenic medication is indicated in the treatment of 
individuals suffering from trypanosomiasis. That the treatment 
ought to be long continued and regularly administered in as high 
doses as the case can stand. That all aids to building up the system 
should be employed’ 
In a fourth paper upon ‘ Atoxyl in the treatment of Trypanoso¬ 
miasis,’ published in the British Medical Journal, Jan, 19th, 1907, by 
Drs. Breinl and Todd, these observ'ers summarised our knowledge 
concerning the use of Atoxyl up to January, ipo/- They quote Van 
Campenhout’s private communication, in which he refers to the 
combination of Atoxyl and Strychnine and a cold bath, the latter for 
a tonic and stimulating effect. TJiree Europeans treated by Van 
Campenhout have gained weight and are apparently well. He has 
obtained good results by the treatment of Europeans by Atoxyl, in 
the first stages of trypanosomiasis. He prefers a solution of 5 P^r 
cent, rather than lo per cent. 
Todd and Breinl recommend the use of a 20 per cent, solution 
administered in increasing doses, up to 0*2 gramme. 
The following letter was published by Professor Ross to make it 
clear that atoxyl was first suggested and used by Thomas and Breinl 
in trypanosomiasis and sleeping sickness in man, as fully established 
in the preceding pages. 
THE TREATMENT OF TRYPANOSOMIASIS. 
Sir, — Many statements having been made recently in the lay press 
to the effect that trypanosomiasis has been cured by various persons 
by the means of atoxyl, I should like to point out that this drug was 
first suggested and used by Drs. Thomas and Breinl, of this School, 
for the purpose referred to. A full account of their experiments was 
given in the Proceedings of the Royal Society, November 9th, 1905, 
vol. 76, and also in our publications, Memoir XVI. At the instance 
of this .School large quantities of the drug have been sent to the 
