20 
'Rabbit, 889, inoculated October 26: weight, l.7t)0 grammes. 
Blood count: reds, 6,620,000; whites, 6,700; haemoglobin, eighty- 
nine per cent. Parasites were seen from November 8 up to January 
10: the trypanosomes were always present but in smalt numbers; 
they then increased to eighteen to twenty to a field. The anaemia 
was pronounced, and loss of weight was noted. It then weighed 
1,540 grammes. Blood count ; red. 3,880.000 ; white. 11.800; haemo¬ 
globin, sixty-three per cent. It could hardly sit up. and remained 
most of the time lying dow'n. This animal was given 0‘8cc. of five 
per cent, solution atoxyl. At the end of eighteen hours the parasites 
were absent from the blood. Doses were given twice a week, 
beginning with 0’5 c.c, and increasing to 2'oc.c. of a five per rent, 
solution. The blood in large doses is non-infective. The animal is 
vivacious, the coat is smooth and thick. Average weight, 1,600 
grammes. Several guinea-pigs infected for about two months, and 
showing twenty to forty parasites to a field, have been treated. They 
were injected subcutaneously with 0-3 c.c. of ten per cent, solution. 
At the end of the fifteenth hour no parasites were seen. Treatment 
was o-i to 0-3 c.c. of five per cent, solution three times a week for two 
months. The animals all increased in weight. One died sixty-two 
days after treatment was discontinued. Three rats inoculated with 
Its blood never became infected. The second and third pigs were 
killed at the end of eighty and one hundred days after stopping 
reatment, and the blood used to inoculate controls. No control has 
shown the parasites. 
Inoculated 
November ,6. Blood count , red, 5,220,000; white, 12,800- haemo- 
set" “T' Parashes were 
The'weilht ^ were noted 
gm was 2,420 grammes. Blood count- red 
wh.te, 7,200; haemoglobin, seventy-three per cent' Th ’ 
counted per mm.=i gave looooo u ' Parasites 
g«ivc 100,000. Oedema of the evelidc u -j 
of nose was nresenf .1 eyelids and bridge 
1 the animal was giv'en 0'8 rr r>P 
solution atoxyl subcutaneously. Four l.otL I i i 
white, 24,800: parasites"roo^‘ ^ 
4.740,000; white, 25,200- narasit^ eighth hour : red. 
Between the fourth and eighth ho ^ eighty-nine fields. 
become remarkably degenerated - Parasites were seen to 
y egenerated and deformed ; many phagocytes 
