i6 
Animals Used 
T. gambiense. —Monkeys, dogs, pups, kittens, rabbits, guinea-pigs, 
rats and mice. 
T. evansi .— Rabbits, guinea-pigs, dogs, rats, mice. 
T. brucei.— Rabbits, guinea-pigs, rats, mice. 
T. equinum. Dogs, rabbits, guinea-pigs, rats and mice. 
T. equiperdum.- Pups. 
T. dimorphu 7 ». Dogs, pups, rabbits, guinea-pigs, rats ami- mice. 
We reproduce also his conclusions upon the advantages of Atoxyl 
in trypanosomiasis: — 
‘ With five exceptions every animal has had one or more controls 
which were infected at the same time ; the controls of T. gambiense^ 
strain ‘ r,’surra, nagana, caderas, and Gambian horse parasites have 
all died in the usual time. It is, therefore, evident, from the great 
majority of the. experiments, tliat the treatment of animals infected 
with trypanosomes with this preparation or in combination with the 
dye either arrests the disease, thus prolonging the life of the animals, 
or apparently cures them, This is especially the case in animals 
irifected with the ordinary strain of T. ga)nbiense, and even, though 
to a less extent, with the abnormally virulent strain called ‘ e! 
A comparison of animals infected with the same strains, but 
treated according to Laveran's method with sodium arseniate has 
made me conclude that treatment with this aniline compound is in 
many ways superior to the ordinary arsenical treatment, on account 
of the quicker action of the drug on the parasite, the fact that the 
action seems to be prolonged, that large doses can be given without 
toxic symptoms and the entire absence from any tendency to cause 
sloughing. 
' In my opinion treatment is indicated, of cases of trypanosomiasis 
m man, with this drug in high doses administered intravenously and 
for a long period, pushing it to the maximal amount that the ca« can 
stand without headache and nausea, at the same time bu.ldmg up 
h Tnaem r TnVp ““^uce to a lessening of 
tissues and secretions, but the na Hve el.bt of 
conjunctivae and staining of the secretions. LV^f 
