15 
to the notice of the medical profession the superior claims of Atoxyl 
as a curative agent in cases of trypanosomiasis. Before, however, 
recommending it to the profession, they put it to a most searching 
test in animals. We quote Thomas’s own wordsTentative 
experiments on rats and rabbits appeared so favourable that I 
decided to institute a series of experiments. These observations 
have been in progress for the last ten months, and have on the whole 
been most promising. In all my therapeutic experiments certain 
conditions were laid down to be followed out. 
1. That the animal should be well infected and the presence of 
parasites determinable in its blood 
2. That the disease should have been established some time 
(one cannot expect to treat either man or beast suffering from the 
disease in the very early stages when no definite symptoms are 
manifested). 
3. That some symptoms besides the presence of parasites should 
be in evidence: 
(<^) Anemia; 
{d) Loss of weight. 
‘ If the treatment of such infected laboratory animals be successful, 
then such a line of medication ought to be of service in the practical 
treatment of the disease. 
Trypanosomes 
The trypanosomes experimented with are the following: — 
T ryfanosoma gambiense — 
(<2) Gambian fever strain (Gunjur). 
(b) Congo Free State fever strain. 
(c) Uganda sleeping sickness. 
{( 1 ) Congo Free State sleeping sickness. 
(«) A highly virulent strain derived from one of my cases of 
sleeping sickness which had only been passed through a 
monkey, baboon, and a rabbit. 
Trypanosoma brucei (nagana). 
Trypanosoma evansi (surra). 
Trypanosoma equinum (mal de Caderas). 
Trypanosoma eqniperdum (dourine). 
Trypanosoma dimorphiim (Gambian horse disease). 
