14 
so well in the case of animals artificially inoculated with T. gamhiense, 
so it might succeed in man in the case of sleeping sickness. 
Ato^rS*trypiio- THOMAS, however, as we have seen, had given it up on account 
somiasis in animals of the nephritis and local necrosis which was induced, and set himself 
to find a preparation of Arsenic less toxic than Arscnious acid or 
Sodium arseniate, and the subcutaneous injection of which produced 
less danger of necrosis. An aniline compound, the anilide of met- 
arsenious acid {A^oxyi), having the supposed formula C„H,NH AsO^ 
attracted his attention. This preparation had been before the medical 
profession since igoo, and various workers had recorded its use in 
the treatment of various skin affections and in anaemia. 
F. Blumenthal, in a paper ‘ Uber Metaarsensaure anilid ’ (Die 
medizmische Woche., 14th April. 1902, No. 15), describes how he had 
used Atoxyl on rabbits in order to test the toxicity of the drug. He 
concluded from his experiments that Atoxyl was 40 times less toxic 
than Solutio Powleri. 
SCHILD (Berl. klin. Wochenschrift, 1902, No. 23, and Dermato- 
ogische Zeitschrift, Band X, Heft r, 1903) employed Atoxyl against 
1 erent skin diseases as psoriasis, lichen ruber, etc, with very good 
results. 
F. Biringer published in the Therapeutische Monatshefte, 
™ Erfahrungen mit Atoxyl’ He 
result d" different skin diseases, and as a 
result regarded it as a valuable and welcome substitute for Arsenious 
entid.^''^Ube'"d" ‘’S’"; Wochenschrift, 
Atoxyl admt t ^ ^^ ^"^ Tuberkulose mit Atoxyl,’ employed 
especially suitable for either subcutane""^"*^’ ■ 
tion. It produces no ^ or intravenous administra- 
of arsenic can be given wffhout tod;""'' 
myself; wrote Thomas, ‘ /ried the d results. ‘ I hare 
loithout ill effects' ' high doses intravenously 
hiiving, after a very clr^uHr ^^^dit of 
ery careful experimental investigation, introduced 
