13 
and mice infected with Mbori or Surra. In the case of animals 
infected with T. gambiense the results appeared to him less 
encouraging. 
In a second paper upon the mixed treatment, published April 
17th, 1905, in the Comptes rendus de I’Academie des Sciences he 
discusses the combined treatment of monkeys infected with 
T. gambiense. His observations confirm the results previously 
obtained with other animals. We reproduce his own comments upon 
the combined treatment in the case of T. gambiense. 
' II n’y a pas de motif pour que le traitement qui a reussi dans les 
infections experimentales du rat, du chien et des singes par 
Trypanosoma gambiense ne reussisse pas egalement dans les infec¬ 
tions naturelles, chez I’homme, et je crois que, des maintenant on 
serail autorise a essayer de ce traitement chez les sujets atteints de 
trypanosomiase. La difficulte sera de determiner les doses d’acides 
arsenieux et de trypanroth qui devront etre prescrites; des tatonne- 
ments seront inevitables. Les chances de succes seront d’autant 
plus grandes que la maladie sera a une periode moins avancee de son 
evolution. II est douteux que le traitement puisse donner encore de 
bons resultats quand les accidents du cote du systeme cerebrospinal 
ont acquis une certaine intensite: on se rappellera d’autre part que 
le trypanroth est irritant pour les reins (r), on surveillera les urines 
et Ton ne prescrira pas ce medicament aux malades atteints de 
nephrite.’ 
FrankE (loc. cit.) also strongly recommended, as the result of his 
extensive trials, the use of the Trypan-red-arsenic treatment. 
WendelstaDT and FeLLMER also advocate the treatment with a 
combination of Arsenic and Brilliant green. They also combine 
Brilliant green and Nucleinic acid. 
Magalhaes, in a paper entitled ‘ De I’Action des Composes 
arsenicaux et du vert brilliant sur le Tryp. ■ gambiense et le Tryp. 
brucei' (Arch. de. R. Inst. bact. Camera pestana, T. I, Jan. 2nd, 1907), 
treated rats infected with T. gambiense with Sodium arseniate and 
Brilliant green. The parasites disappeared for a time but reappeared 
again. 
As seen from the above notes, the combined Arsenic-colour 
treatment led Laveran to believe that as it had succeeded in his hands 
