6 
I “ 
"i 
. , -i 
■ n 
Sodium arseniate 
of its blood, 
note was made 
perfect health, 
Tramway Company. ‘ On the morning of the yth October, 1892, the 
" Surra ” haematozoon was discovered on microscopical examination 
On admission to the l^aboratory Hospital the following 
;—“Bay gelding, aged five years; appears to be in 
_ _, and in splendid condition.” On this date the 
haematozoon was absent from the blood, while for the next two days 
it was swarming: specific treatment was deferred, a simple febrifuge 
draught being given to try and reduce the temperature. On the 
evening of the 12th October, the organism was only present in small 
numbers in the blood, and the temperature had decreased 
considerably, as had also the pulse. It was decided to again attempt 
the destruction of the haematozoon by the exhibition of Cinchona 
Alkaloids and Arsenic, commencing in this instance with large 
doses (viz., Alkaloid drs. iii, and Arsenic grains iv, bis die). 
The reason why large doses of the former were exhibited was 
that few haematozoa remained in the blood, and in order to 
decide whether their destruction could be compassed by the 
drug, the dose was so regulated as to ensure its having a fair 
trial. No marked change took place in the animal’s condition, nor in 
the number of the organisms present, until the lOth instant, when 
the haematozoa became numerous, the temperature rose considerably, 
respirations were increased in number, and it was noticed that the 
sheath was swollen ; the treatment was continued, the dose of Arsenic 
having been gradually raised to six grains. On the i;th the 
organisms had again fallen to few, but the temperature and pulse 
were stiU above normal. On this date it was decided to try the effect 
of full doses of Quinine, as this drug has been said to be of much 
value when exhibited in this manner. Ranking has stated that “ by 
the employment of full doses of Quinine and Arsenic he has been able 
to cure the disease. It appeared from our previous experiments on 
the use of similar drugs, that it would be futile to attempt the 
destruction of the haematozoa by giving only the full medicinal dose, 
and we considered it to be advisable therefore to commence with a 
dose of drs. iv of quinine, and arsenic grains x.i, in the 24 hours, 
jefully watching its effects, and in case of any untoward symptom 
appearing, to discontinue its use.’ ^ ^ 
llnstitut Pasteur their researches ' Sur le Traitement et la prevention 
