globes widely separated from one another, and connected by a 
generally curved and tapering mass of substance which seems to have 
been simply drawn out between them. At the same time the outer 
nuclear substance collects about the diverging daughter elements, and 
finaOy separates along with them into two smaller masses, which, 
together with the new intra-nuclear centrosomes, eventually 
reproduce two complete and round nuclei, exactly like the parent 
nucleus only smaller. The process of nuclear division just described 
may be rapidly repeated; and at the same time the original 
trypanosome loses its characteristic form, and become rounded up so 
as to produce the well-known multi-nucleated masses such as those 
represented in figs. 12-25. some cases, however, when the nucleus, 
in a specimen such as that represented in fig. 19 has divided, the 
trypanosomes may become longitudinally split as in fig. 39, and in 
these cases the nuclei may at the same time travel towards the extra- 
nuclear centrosome so as to occupy the position represented in fig 39 - 
The ends of these division products may become detached from one 
another, and a very curious appearance result, represented in fig. 39 * 
We think that the features of this form of division at the period we 
are discussing deserves particular attention, for the appearances 
produced when it occurs are indistinguishable from the figures given 
by Prowazek, and interpreted by him as conjugation. 
We have, however, found nothing in relation to the nuclei, or any 
other structure in such cells, when in this condition, to suggest that 
the forms in question can be interpreted as conjugation. When such 
forms are produced, their future history appears to be this: Either 
the nuclei divide further, and the separation remains incomplete, the 
hnal product being one of the irregular multi-nucleated forms, or the 
bssion is completed and the daughter cells, each after further nuclear 
divisions, produce fresh multi-nucleated masses. 
We have referred to this process because of its obvious bearing 
upon the interpretation to be put upon the identical figures given by 
Prowazek. Our observations indicate that it is relatively a rare 
method of procedure, the more normal processes being the 
multiplication of the nuclei and the rounding up of the trypano 
^me to produce eventually the multi-nucleated masses. During 
period, i.e., the time and after the body becomes detached 
horn the extra-nuclear centrosome the history of this latter 
