233 
CONTRIBUTIONS 
TO THE MORPHOLOGY AND LIFE 
HISTORY OF PIRO PLASMA CAN IS 
BY 
ANTON BREINL, 
mRECTOR OF THE RUNCORN RESEARCH LAB..RAICH.RR. UVKKP.M.I. SCH-.OL OF 
TROl'ICAI. MEDICINE 
AND 
EDWARD HINDEE. 
DEMONSTRATOR AM. KK.sEARCH ASSISTANT oF THE KUNCoBN RESEARCH 
I-ABORATORIKS 
(Received for publication 13 May, 1908^ 
Ptroplasma canis was discovered by Piana and Galli-Valeno in 
the year 1895,and, on account of its wide distribution and the ease 
with which experimental infection can be transmitted from dog to dog, 
this parasite has been the subject of extensive study. It seems 
unnecessary to give a complete review of the literature, especially 
since Nuttall and Graham-Smith,and more recently Christophers, 
have given fairly complete bibliographies. 
Additional interest has been attached to Piroplasmata in genera 
since the appearance of Schaudinn's^*^ work, in which he mentions 
(p. 428) Kossel’s and Weber’s observation, and suggests that 
Piroplasma may pass through a life cycle similar to t at o 
Halteridium. However, very little evidence in support of this 
hypothesis has been brought forward by later workers. 
The parasite, on which the following observations were based, was 
obtained from Professor Uhlenhuth, of Berlin, to whom we have 
pleasure in expressing our indebtedness. The strain has been ep 
going in pups and dogs by means of simple inoculation. In our 
it has shown itself very virulent, even in the case of full-grown og , 
wd no animal survived the infection. Young dogs showed para 
in scanty number, two to three days after an intra-peritonea mjec 1 
of I to 2 C.C. of heavily-infected blood; their number increase 
slowly during the following 24 hours; after this a rapid 
the number of parasites set in. Within 40 hours a ter 
